Literature DB >> 9560334

G-protein signaling: fine-tuning signaling kinetics.

N Zerangue1, L Y Jan.   

Abstract

Mammalian 'regulators of G protein signaling' (RGS proteins) help shut off G-protein-mediated signaling by GTPase activation. But new evidence shows that RGS proteins can also speed up the activation of signaling. The combined effect is a change in signaling kinetics without a decrease in signaling intensity.

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Year:  1998        PMID： 9560334     DOI： 10.1016/s0960-9822(98)70196-4

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  18 in total

Review 1.  G-protein coupled receptor kinases as modulators of G-protein signalling.

Authors:  M Bünemann; M M Hosey
Journal:  J Physiol       Date:  1999-05-15       Impact factor: 5.182

2.  Endogenous regulators of G protein signaling proteins regulate presynaptic inhibition at rat hippocampal synapses.

Authors:  H Chen; N A Lambert
Journal:  Proc Natl Acad Sci U S A       Date:  2000-11-07       Impact factor: 11.205

3.  Regulators of G-protein signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity.

Authors:  Nevin A Lambert; Christopher A Johnston; Steven D Cappell; Sudhakiranmayi Kuravi; Adam J Kimple; Francis S Willard; David P Siderovski
Journal:  Proc Natl Acad Sci U S A       Date:  2010-03-29       Impact factor: 11.205

Review 4.  The ß subunit of voltage-gated Ca2+ channels.

Authors:  Zafir Buraei; Jian Yang
Journal:  Physiol Rev       Date:  2010-10       Impact factor: 37.312

Review 5.  Regulation and physiological functions of G12/13-mediated signaling pathways.

Authors:  Nobuchika Suzuki; Nicole Hajicek; Tohru Kozasa
Journal:  Neurosignals       Date:  2009-02-12

Review 6.  Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.

Authors:  Adam J Kimple; Dustin E Bosch; Patrick M Giguère; David P Siderovski
Journal:  Pharmacol Rev       Date:  2011-07-07       Impact factor: 25.468

7.  Rapid GTP binding and hydrolysis by G(q) promoted by receptor and GTPase-activating proteins.

Authors:  S Mukhopadhyay; E M Ross
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

8.  Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes.

Authors:  Alethia Villasenor; Zhao V Wang; Lee B Rivera; Ozhan Ocal; Ingrid Wernstedt Asterholm; Philipp E Scherer; Rolf A Brekken; Ondine Cleaver; Thomas M Wilkie
Journal:  Dis Model Mech       Date:  2010-07-08       Impact factor: 5.758

9.  New roles for RGS2, 5 and 8 on the ratio-dependent modulation of recombinant GIRK channels expressed in Xenopus oocytes.

Authors:  S Herlitze; J P Ruppersberg; M D Mark
Journal:  J Physiol       Date:  1999-06-01       Impact factor: 5.182

10.  Activation of leukemia-associated RhoGEF by Galpha13 with significant conformational rearrangements in the interface.

Authors:  Nobuchika Suzuki; Kouhei Tsumoto; Nicole Hajicek; Kenji Daigo; Reiko Tokita; Shiro Minami; Tatsuhiko Kodama; Takao Hamakubo; Tohru Kozasa
Journal:  J Biol Chem       Date:  2008-12-12       Impact factor: 5.157
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