Literature DB >> 9559825

Human cytomegalovirus mutant with sequence-dependent resistance to the phosphorothioate oligonucleotide fomivirsen (ISIS 2922).

G B Mulamba1, A Hu, R F Azad, K P Anderson, D M Coen.   

Abstract

A human cytomegalovirus mutant that was isolated for resistance (10-fold) to the antisense oligonucleotide fomivirsen (ISIS 2922) exhibited cross-resistance to a modified derivative of fomivirsen with an identical base sequence but little or no resistance to an oligonucleotide with an unrelated sequence. No changes in the mutant's DNA corresponding to the fomivirsen target sequence were found.

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Year:  1998        PMID： 9559825      PMCID： PMC105584          DOI： 10.1128/AAC.42.4.971

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  8 in total

1.  Isolation of foscarnet-resistant human cytomegalovirus patterns of resistance and sensitivity to other antiviral drugs.

Authors:  V Sullivan; D M Coen
Journal:  J Infect Dis       Date:  1991-10       Impact factor: 5.226

Review 2.  The implications of resistance to antiviral agents for herpesvirus drug targets and drug therapy.

Authors:  D M Coen
Journal:  Antiviral Res       Date:  1991-05       Impact factor: 5.970

3.  Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus.

Authors:  D M Coen; H E Fleming; L K Leslie; M J Retondo
Journal:  J Virol       Date:  1985-02       Impact factor: 5.103

4.  Inhibition of human cytomegalovirus immediate-early gene expression by an antisense oligonucleotide complementary to immediate-early RNA.

Authors:  K P Anderson; M C Fox; V Brown-Driver; M J Martin; R F Azad
Journal:  Antimicrob Agents Chemother       Date:  1996-09       Impact factor: 5.191

5.  A working hypothesis--virus resistance development as an indicator of specific antiviral activity.

Authors:  E C Herrmann; J A Herrmann
Journal:  Ann N Y Acad Sci       Date:  1977-03-04       Impact factor: 5.691

6.  Antiviral activity of a phosphorothioate oligonucleotide complementary to RNA of the human cytomegalovirus major immediate-early region.

Authors:  R F Azad; V B Driver; K Tanaka; R M Crooke; K P Anderson
Journal:  Antimicrob Agents Chemother       Date:  1993-09       Impact factor: 5.191

7.  A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives.

Authors:  V Sullivan; K K Biron; C Talarico; S C Stanat; M Davis; L M Pozzi; D M Coen
Journal:  Antimicrob Agents Chemother       Date:  1993-01       Impact factor: 5.191

8.  Mutations in the herpes simplex virus major DNA-binding protein gene leading to altered sensitivity to DNA polymerase inhibitors.

Authors:  H C Chiou; S K Weller; D M Coen
Journal:  Virology       Date:  1985-09       Impact factor: 3.616
  8 in total
  23 in total

1.  Recombinant green fluorescent protein-expressing human cytomegalovirus as a tool for screening antiviral agents.

Authors:  M Marschall; M Freitag; S Weiler; G Sorg; T Stamminger
Journal:  Antimicrob Agents Chemother       Date:  2000-06       Impact factor: 5.191

2.  Effective inhibition of human cytomegalovirus gene expression and replication by a ribozyme derived from the catalytic RNA subunit of RNase P from Escherichia coli.

Authors:  P Trang; M Lee; E Nepomuceno; J Kim; H Zhu; F Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-23       Impact factor: 11.205

3.  Phosphorylation of beta-D-ribosylbenzimidazoles is not required for activity against human cytomegalovirus.

Authors:  Paula M Krosky; Katherine Z Borysko; M Reza Nassiri; Rodrigo V Devivar; Roger G Ptak; Michelle G Davis; Karen K Biron; Leroy B Townsend; John C Drach
Journal:  Antimicrob Agents Chemother       Date:  2002-02       Impact factor: 5.191

Review 4.  Human cytomegalovirus resistance to antiviral drugs.

Authors:  C Gilbert; G Boivin
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

Review 5.  Fate-Regulating Circuits in Viruses: From Discovery to New Therapy Targets.

Authors:  Anand Pai; Leor S Weinberger
Journal:  Annu Rev Virol       Date:  2017-08-11       Impact factor: 10.431

6.  Virucidal activity of a GT-rich oligonucleotide against herpes simplex virus mediated by glycoprotein B.

Authors:  Benjamin Shogan; Lori Kruse; Gilbert B Mulamba; André Hu; Donald M Coen
Journal:  J Virol       Date:  2006-05       Impact factor: 5.103

7.  RNA interference-mediated targeting of human cytomegalovirus immediate-early or early gene products inhibits viral replication with differential effects on cellular functions.

Authors:  E Xiaofei; Bradford M Stadler; Michelle Debatis; Shixia Wang; Shan Lu; Timothy F Kowalik
Journal:  J Virol       Date:  2012-03-21       Impact factor: 5.103

8.  RNase P-mediated inhibition of cytomegalovirus protease expression and viral DNA encapsidation by oligonucleotide external guide sequences.

Authors:  W Dunn; P Trang; U Khan; J Zhu; F Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2001-12-11       Impact factor: 11.205

Review 9.  Fomivirsen.

Authors:  C M Perry; J A Balfour
Journal:  Drugs       Date:  1999-03       Impact factor: 9.546

Review 10.  Antisense, RNAi, and gene silencing strategies for therapy: mission possible or impossible?

Authors:  Elizabeth R Rayburn; Ruiwen Zhang
Journal:  Drug Discov Today       Date:  2008-05-03       Impact factor: 7.851
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