Literature DB >> 9559810

Effect of grapefruit juice on clarithromycin pharmacokinetics.

K L Cheng1, A N Nafziger, C A Peloquin, G W Amsden.   

Abstract

To investigate whether grapefruit juice inhibits the metabolism of clarithromycin, 12 healthy subjects were given water or grapefruit juice before and after a clarithromycin dose of 500 mg in a randomized crossover study. Administration of grapefruit juice increased the time to peak concentration of both clarithromycin (82 +/- 35 versus 148 +/- 83 min; P = 0.02) and 14-hydroxyclarithromycin (84 +/- 38 min versus 173 +/- 85; P = 0.01) but did not affect other pharmacokinetic parameters.

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Year:  1998        PMID： 9559810      PMCID： PMC105569          DOI： 10.1128/AAC.42.4.927

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

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Journal:  Antimicrob Agents Chemother       Date:  1993-10       Impact factor: 5.191

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Journal:  Clin Pharmacol Ther       Date:  1995-05       Impact factor: 6.875

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Journal:  Antimicrob Agents Chemother       Date:  1992-11       Impact factor: 5.191
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  11 in total

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Authors:  K A Rodvold
Journal:  Clin Pharmacokinet       Date:  1999-11       Impact factor: 6.447

Review 6.  The effect of grapefruit juice on drug disposition.

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Journal:  Expert Opin Drug Metab Toxicol       Date:  2011-01-22       Impact factor: 4.481

Review 7.  Grapefruit-drug interactions.

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Journal:  Clin Pharmacokinet       Date:  1999-09       Impact factor: 6.447

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Journal:  Nutr J       Date:  2007-10-30       Impact factor: 3.271

10.  Pharmacokinetic drug interactions of antimicrobial drugs: a systematic review on oxazolidinones, rifamycines, macrolides, fluoroquinolones, and Beta-lactams.

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