Literature DB >> 8262691

TopFit: a PC-based pharmacokinetic/pharmacodynamic data analysis program.

P Tanswell1, J Koup.   

Abstract

The program TopFit was developed and validated within the European pharmaceutical industry. It provides both pharmacokinetic data analysis support for international regulatory submissions of new drugs, and sophisticated techniques for model-based kinetic/dynamic evaluation during drug development. TopFit features are: (1) non-compartmental methods; (2) standard compartment models assembled from input and disposition modules; (3) a potentially unlimited number of linear user-defined models that accommodate metabolites, effects, and absorption profiles; (4) a library of 24 non-linear models. No user programming is required. A well-defined file structure allows ready exchange of data with other programs such as SAS. TopFit version 2.0 is now commercially available, with comprehensive documentation, in the form of an MS-DOS application for the PC.

Mesh：

Year:  1993        PMID： 8262691

Source DB:  PubMed          Journal:  Int J Clin Pharmacol Ther Toxicol        ISSN： 0174-4879


  20 in total

1.  Pharmacokinetics and safety of ascending single doses of DZ-2640, a new oral carbapenem antibiotic, administered to healthy Japanese subjects.

Authors:  M Tanaka; K Kato; H Hakusui; Y Murakami; K Sato; Y Ito; K Kawamoto
Journal:  Antimicrob Agents Chemother       Date:  2000-03       Impact factor: 5.191

2.  Pharmacokinetics and pharmacodynamics of gatifloxacin against Streptococcus pneumoniae and Staphylococcus aureus in a granulocyte-rich exudate.

Authors:  Andrej Trampuz; Gerd Laifer; Markus Wenk; Zarko Rajacic; Werner Zimmerli
Journal:  Antimicrob Agents Chemother       Date:  2002-11       Impact factor: 5.191

3.  Lack of effect of zafirlukast on the pharmacokinetics of azithromycin, clarithromycin, and 14-hydroxyclarithromycin in healthy volunteers.

Authors:  K W Garey; C A Peloquin; P G Godo; A N Nafziger; G W Amsden
Journal:  Antimicrob Agents Chemother       Date:  1999-05       Impact factor: 5.191

4.  An extremely strange observation?

Authors:  Helmut Schütz
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2004 Jan-Mar       Impact factor: 2.441

5.  Comparative pharmacokinetics of gentamicin after intravenous, intramuscular, subcutaneous and oral administration in broiler chickens.

Authors:  E A Abu-Basha; N M Idkaidek; A F Al-Shunnaq
Journal:  Vet Res Commun       Date:  2007-02-01       Impact factor: 2.459

6.  The lignocaine metabolite (MEGX) liver function test and P-450 induction in humans.

Authors:  C Reichel; T Skodra; A Nacke; U Spengler; T Sauerbruch
Journal:  Br J Clin Pharmacol       Date:  1998-12       Impact factor: 4.335

7.  Pharmacokinetics in serum and leukocyte exposures of oral azithromycin, 1,500 milligrams, given over a 3- or 5-day period in healthy subjects.

Authors:  G W Amsden; A N Nafziger; G Foulds
Journal:  Antimicrob Agents Chemother       Date:  1999-01       Impact factor: 5.191

8.  Effect of grapefruit juice on clarithromycin pharmacokinetics.

Authors:  K L Cheng; A N Nafziger; C A Peloquin; G W Amsden
Journal:  Antimicrob Agents Chemother       Date:  1998-04       Impact factor: 5.191

9.  Treosulfan, Fludarabine, and Low-Dose Total Body Irradiation for Children and Young Adults with Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Allogeneic Hematopoietic Cell Transplantation: Prospective Phase II Trial of the Pediatric Blood and Marrow Transplant Consortium.

Authors:  Eneida R Nemecek; Ralf A Hilger; Alexia Adams; Bronwen E Shaw; Deidre Kiefer; Jennifer Le-Rademacher; John E Levine; Gregory Yanik; Wing Leung; Julie-An Talano; Paul Haut; David Delgado; Neena Kapoor; Aleksandra Petrovic; Roberta Adams; Rabi Hanna; Hemalatha Rangarajan; Jignesh Dalal; Joseph Chewning; Michael R Verneris; Stacy Epstein; Lauri Burroughs; Evelio D Perez-Albuerne; Michael A Pulsipher; Colleen Delaney
Journal:  Biol Blood Marrow Transplant       Date:  2018-05-09       Impact factor: 5.742

10.  Delta-9-tetrahydrocannabinol (THC) serum concentrations and pharmacological effects in males after smoking a combination of tobacco and cannabis containing up to 69 mg THC.

Authors:  Claudine C Hunault; Tjeert T Mensinga; Irma de Vries; Hermien H Kelholt-Dijkman; Jani Hoek; Maaike Kruidenier; Marianne E C Leenders; Jan Meulenbelt
Journal:  Psychopharmacology (Berl)       Date:  2008-08-10       Impact factor: 4.530
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