Literature DB >> 9559

Role of the parietal cell in gastric damage induced by aspirin and related drugs: implications for safer therapy.

K D Rainsford, K Brune.   

Abstract

The proton-secreting parietal cell is shown, from recent evidence, to be the principal focus for the actions of aspirin (and related drugs) in damaging the gastric mucosa. It is suggested that the selective damage to the parietal cells is due to the ph gradient favouring a high rate of aspirin uptake and subsequent entrapment of drug anions inside these cells. This concept may serve as a useful basis for developing procedures to minimize the gastric damage by aspirin and related acidic drugs.

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Year:  1976        PMID： 9559

Source DB:  PubMed          Journal:  Med J Aust        ISSN： 0025-729X            Impact factor:   7.738


  10 in total

1.  Comparative Studies of Gastric Ulcerogenesis by Non-steroid Anti-inflammatory Drugs: Effects of Fenclofenac.

Authors:  K D Rainsford
Journal:  Proc R Soc Med       Date:  1977

2.  'Towards assays of gastro-intestinal toxicity of non-steroid anti-inflammatory drugs with improved predictive value in man'.

Authors:  K D Rainsford
Journal:  Agents Actions       Date:  1977-07

3.  Anti-inflammatory and PG inhibitory effects of phenacetin and acetaminophen.

Authors:  E M Glenn; B J Bowman; N A Rohloff
Journal:  Agents Actions       Date:  1977-12

4.  Selective cytotoxic actions of aspirin on parietal cells: a principal factor in the early stages of aspirin-induced gastric damage.

Authors:  K D Rainsford; K Brune
Journal:  Arch Toxicol       Date:  1978-04-27       Impact factor: 5.153

5.  The role of aspirin in gastric ulceration . Some factors involved in the development of gastric mucosal damage induced by aspirin in rats exposed to various stress conditions.

Authors:  K D Rainsford
Journal:  Am J Dig Dis       Date:  1978-06

6.  Structure-activity relationships of non-steroid anti-inflammatory drug 1. Gastric ulcerogenic activity.

Authors:  K D Rainsford
Journal:  Agents Actions       Date:  1978-12

7.  The comparative gastric ulcerogenic activities of non-steroid anti-inflammatory drugs.

Authors:  K D Rainsford
Journal:  Agents Actions       Date:  1977-12

8.  Anti-inflammatory/anti-pyretic salicylic acid esters with low gastric ulcerogenic activity.

Authors:  K D Rainsford; M W Whitehouse
Journal:  Agents Actions       Date:  1980-11

9.  The influence of paracetamol on the erosive activity of indomethacin in the rat stomach.

Authors:  A A van Kolfschoten; P Zandberg; L P Jager; J van Noordwijk
Journal:  Agents Actions       Date:  1982-04

10.  Antiulcer effect of the methanolic extract of Tamarindus indica seeds in different experimental models.

Authors:  Pankaj Kalra; Sunil Sharma; Suresh Kumar
Journal:  J Pharm Bioallied Sci       Date:  2011-04
  10 in total

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