Literature DB >> 414527

Anti-inflammatory and PG inhibitory effects of phenacetin and acetaminophen.

E M Glenn, B J Bowman, N A Rohloff.   

Abstract

Although acetaminophen and phenacetin do not inhibit PG synthesis when added directly to isolated rat platelets and when given orally, both drugs inhibit carrageenan-induced hindpaw edema--a widely used inflammatory assay method. It does not appear that the anti-inflammatory effects of these non-steroidal drugs (unlike other well-known non-steroidal drugs) can be explained on the basis of PG-synthetase inhibition.

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Year:  1977        PMID： 414527     DOI： 10.1007/bf02111123

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  8 in total

1.  Role of the parietal cell in gastric damage induced by aspirin and related drugs: implications for safer therapy.

Authors:  K D Rainsford; K Brune
Journal:  Med J Aust       Date:  1976-06-05       Impact factor: 7.738

2.  Characterization of antibody to prostaglandin F 2a .

Authors:  K T Kirton; J C Cornette; K L Barr
Journal:  Biochem Biophys Res Commun       Date:  1972-05-26       Impact factor: 3.575

3.  Platelets, prostaglandins, red cells, sedimentation rates, serum and tissue proteins and non-steroidal anti-inflammatory drugs.

Authors:  E M Glenn; J Wilks; B J Bowman
Journal:  Proc Soc Exp Biol Med       Date:  1972-12

4.  Role of prostaglandin endoperoxide PGG2 in inflammatory processes.

Authors:  F A Kuehl; J L Humes; R W Egan; E A Ham; G C Beveridge; C G Van Arman
Journal:  Nature       Date:  1977-01-13       Impact factor: 49.962

5.  Urea compounds that increase the biosynthesis of prostaglandins in vivo--in vitro.

Authors:  E M Glenn; D A Rector; B J Bowman; N A Rohloff
Journal:  Agents Actions       Date:  1977-12

6.  In vivo suppression of prostaglandin biosynthesis by non-steroidal anti-inflammatory agents.

Authors:  F A Fitzpatrick; M A Wynalda
Journal:  Prostaglandins       Date:  1976-12

7.  Quantitative comparison of the analgesic and anti-inflammatory activities of aspirin, phenacetin and acetaminophen in rodents.

Authors:  R Vinegar; J F Truax; J L Selph
Journal:  Eur J Pharmacol       Date:  1976-05       Impact factor: 4.432

8.  Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol).

Authors:  R J Flower; J R Vane
Journal:  Nature       Date:  1972-12-15       Impact factor: 49.962
  8 in total
  9 in total

1.  Double-blind, placebo controlled comparison of paracetamol and paracetamol plus codeine--a quantitative evaluation by laser induced pain.

Authors:  L Arendt-Nielsen; J C Nielsen; P Bjerring
Journal:  Eur J Clin Pharmacol       Date:  1991       Impact factor: 2.953

2.  Nitroparacetamol exhibits anti-inflammatory and anti-nociceptive activity.

Authors:  O A al-Swayeh; L E Futter; R H Clifford; P K Moore
Journal:  Br J Pharmacol       Date:  2000-08       Impact factor: 8.739

3.  Anomalous biological effects of salicylates and prostaglandins.

Authors:  E M Glenn; B J Bowman; N A Rohloff
Journal:  Agents Actions       Date:  1979-08

Review 4.  The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings.

Authors:  Garry G Graham; Michael J Davies; Richard O Day; Anthoulla Mohamudally; Kieran F Scott
Journal:  Inflammopharmacology       Date:  2013-05-30       Impact factor: 4.473

5.  The dose-related effects of paracetamol on hyperalgesia and nociception in the rat.

Authors:  M Bianchi; A E Panerai
Journal:  Br J Pharmacol       Date:  1996-01       Impact factor: 8.739

6.  Methodological considerations in the evaluation of analgesic combinations: acetaminophen (paracetamol) and hydrocodone in postpartum pain.

Authors:  W T Beaver; D McMillan
Journal:  Br J Clin Pharmacol       Date:  1980-10       Impact factor: 4.335

7.  Paracetamol versus placebo: effects on post-operative course.

Authors:  P Skjelbred; P Løkken
Journal:  Eur J Clin Pharmacol       Date:  1979-02-19       Impact factor: 2.953

8.  Arachidonate metabolism via lipoxygenase and 12L-hydroperoxy-5,8,10,14-icosatetraenoic acid peroxidase sensitive to anti-inflammatory drugs.

Authors:  M I Siegel; R T McConnell; N A Porter; P Cuatrecasas
Journal:  Proc Natl Acad Sci U S A       Date:  1980-01       Impact factor: 11.205

9.  Analgesic and anti-inflammatory effects of paracetamol evaluated by bilateral oral surgery.

Authors:  P Løkken; P Skjelbred
Journal:  Br J Clin Pharmacol       Date:  1980-10       Impact factor: 4.335
  9 in total

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