Literature DB >> 955679

The mediation of tissue eosinophilia in hypersensitivity reactions. II. Separation of a delayed eosinophil chemotactic factor from macrophage chemotactic factors.

M Hirashima, M Honda, H Hayashi.   

Abstract

In anaphylactic cutaneous lesions induced by DNP-ascaris extract in the guinea-pig, the time-course of delayed tissue eosinophilia was found to parallel that of the macrophage reaction, reaching its peak in 24 h. Macrophages could be differentiated from lymphocytes by the numerous lysosomal granules which stained for acid phosphatase. Extracts from such skin lesions contained a delayed eosinophil chemotactic factor and two different macrophage chemotactic factors. Most of the delayed eosinophil chemotactic factor was separated from the two macrophage chemotactic factors by gel filtration on Sephadex G-100 and Sephadex G-200 in that order. The eosinophil chemotactic factor after re-chromatography on Sephadex G-I99 showed no or little chemotactic activity for macrophages.

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Year:  1976        PMID： 955679      PMCID： PMC1445113     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  17 in total

1.  Proteolytic mechanism in recurrence of Arthus-type inflammation by thiol compounds.

Authors:  H MAYASHI; H MIYOSHI; R NITTA; K UDAKA
Journal:  Br J Exp Pathol       Date:  1962-10

2.  Gel filtration: a method for desalting and group separation.

Authors:  J PORATH; P FLODIN
Journal:  Nature       Date:  1959-06-13       Impact factor: 49.962

3.  Experimental study on the mechanisms of delayed hypersensitivity reaction, with special reference to emigration and function of mononuclear cells.

Authors:  T Kambara; H Katsuya; S Maeda
Journal:  Acta Pathol Jpn       Date:  1972-08

4.  Guinea-pig reaginic antibody. II. Physicochemical and biological properties.

Authors:  R A Margni; S E Hajos
Journal:  Immunology       Date:  1973-08       Impact factor: 7.397

5.  The natural mediator for PMN emigration in inflammation. II. Common antigenicity of leucoegresin with immunoglobulin G.

Authors:  S Yamamoto; M Yoshinaga; H Hayashi
Journal:  Immunology       Date:  1971-05       Impact factor: 7.397

6.  Biologic activity of extracts of delayed hypersensitivity skin reaction sites.

Authors:  S Cohen; P A Ward; T Yoshida; C L Burek
Journal:  Cell Immunol       Date:  1973-12       Impact factor: 4.868

7.  Studies on eosinophil leucocyte migration. I. Eosinophil and neutrophil accumulation following antigen-antibody reactions in guinea-pig skin.

Authors:  A B Kay
Journal:  Clin Exp Immunol       Date:  1970-01       Impact factor: 4.330

8.  The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes.

Authors:  S BOYDEN
Journal:  J Exp Med       Date:  1962-03-01       Impact factor: 14.307

9.  Antibody formation in vitro.

Authors:  M FISHMAN
Journal:  J Exp Med       Date:  1961-12-01       Impact factor: 14.307

10.  An eosinophil leukocyte chemotactic factor of anaphylaxis.

Authors:  A B Kay; D J Stechschulte; K F Austen
Journal:  J Exp Med       Date:  1971-03-01       Impact factor: 14.307
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  12 in total

1.  Isolation of an eosinophil chemotactic lymphokine as a natural mediator for eosinophil chemotaxis from concanavalin A-induced skin reaction sites in guinea-pigs.

Authors:  M Hirashima; K Tashiro; K Sakata; M Hirashima
Journal:  Clin Exp Immunol       Date:  1984-07       Impact factor: 4.330

2.  The regulation of tissue eosinophil chemotactic factor and inhibitor in allergic skin lesions of Freund's complete adjuvant-treated guinea-pigs.

Authors:  M Hirashima; K Tashiro; H Hayashi
Journal:  Immunology       Date:  1984-03       Impact factor: 7.397

3.  Characterization of three macrophage chemotactic factors from PPD-induced delayed hypersensitivity reaction sites in guinea pigs, with special reference to a chemotactic lymphokine.

Authors:  M Honda; H Hayashi
Journal:  Am J Pathol       Date:  1982-08       Impact factor: 4.307

4.  The mediation of tissue eosinophilia in hypersensitivity reactions. V. Comparative study of tissue eosinophilia in the skin lesions of local and systemic passive cutaneous anaphylactic reactions.

Authors:  M Hirashima; K Tashiro; Y Hirotsu; H Hayashi
Journal:  Immunology       Date:  1983-09       Impact factor: 7.397

5.  Selective chemotaxis of Ia antigen-positive blood monocytes in response to a macrophage chemotactic lymphokine extractable from PPD-induced delayed hypersensitivity reaction site in guinea-pigs.

Authors:  T Yoshimura; M Honda; H Hayashi
Journal:  Immunology       Date:  1984-06       Impact factor: 7.397

6.  Lymphocyte chemotaxis in inflammation. III. Demonstration of lymphocyte chemotactic activity in extract from PPD-induced delayed hypersensitivity skin reaction site in the guinea-pig.

Authors:  Y Shimokawa; S Harita; Y Higuchi; H Hayashi
Journal:  Br J Exp Pathol       Date:  1982-08

7.  The regulation of tissue eosinophilia. III. In vitro production of eosinophil-directed chemotactic inhibitory factor by T lymphocytes of complete Freund's adjuvant-treated guinea-pigs.

Authors:  K Tashiro; K Sakata; M Hirashima; H Hayashi
Journal:  Immunology       Date:  1985-05       Impact factor: 7.397

8.  Dexamethasone suppresses concanavalin A-induced production of chemotactic lymphokines by releasing a soluble factor from splenic T lymphocytes.

Authors:  M Hirashima; K Sakata; K Tashiro; T Yoshimura; H Hayashi
Journal:  Immunology       Date:  1985-03       Impact factor: 7.397

9.  The chemical mediation of delayed hypersensitivity skin reaction. II. Characterization of a macrophage-chemotactic factor from bovine gamma-globulin-induced skin reaction in guinea pigs.

Authors:  K Ueda; T Kambara
Journal:  Am J Pathol       Date:  1978-07       Impact factor: 4.307

10.  The mediation of tissue eosinophilia in hypersensitivity reactions. III. Separation of two different delayed eosinophil chemotactic factors and transfer of these factors by serum or cells from sensitized guinea-pigs.

Authors:  Y Hirotsu; M Hirashima; H Hayashi
Journal:  Immunology       Date:  1983-01       Impact factor: 7.397
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