Literature DB >> 955572

A new semisynthesis of human insulin.

R Obermeier, R Geiger.   

Abstract

A new semisynthesis of human insulin starting from porcine insulin is described. NalphaA1, NalphaB1-di-Boc-desoctapeptide-(B23-30)-insulin bearing 6 free carboxyl groups is coupled with the suitably protected human insulin-(B23-30)-octapeptide. The preferred reaction site is the carboxyl group of ArgB22. Side products are eliminated by extensive chromatographic purification.

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Year:  1976        PMID： 955572     DOI： 10.1515/bchm2.1976.357.1.759

Source DB:  PubMed          Journal:  Hoppe Seylers Z Physiol Chem        ISSN： 0018-4888


  10 in total

1.  Biological activity of synthetic human insulin.

Authors:  F Märki; W Albrecht
Journal:  Diabetologia       Date:  1977-08       Impact factor: 10.122

Review 2.  Human insulin: much ado about one amino acid?

Authors:  G E Sonnenberg; M Berger
Journal:  Diabetologia       Date:  1983-12       Impact factor: 10.122

3.  Stabilisation of dissolved proteins against denaturation at hydrophobic interfaces.

Authors:  H Thurow; K Geisen
Journal:  Diabetologia       Date:  1984-08       Impact factor: 10.122

4.  Rapid preparation of human insulin and insulin analogues in high yield by enzyme-assisted semi-synthesis.

Authors:  K Rose; H De Pury; R E Offord
Journal:  Biochem J       Date:  1983-06-01       Impact factor: 3.857

Review 5.  Equivalent Recombinant Human Insulin Preparations and their Place in Therapy.

Authors:  Juergen Sandow; Wolfgang Landgraf; Reinhard Becker; Gerhard Seipke
Journal:  Eur Endocrinol       Date:  2015-04-11

6.  A peptide & peptide nucleic acid synthesis technology for transporter molecules and theranostics--the SPPS.

Authors:  Ruediger Pipkorn; Klaus Braun; Manfred Wiessler; Waldemar Waldeck; Hans-Hermann Schrenk; Mario Koch; Wolfhard Semmler; Dorde Komljenovic
Journal:  Int J Med Sci       Date:  2014-05-07       Impact factor: 3.738

Review 7.  The evolution of insulin glargine and its continuing contribution to diabetes care.

Authors:  Rolf Hilgenfeld; Gerhard Seipke; Harald Berchtold; David R Owens
Journal:  Drugs       Date:  2014-06       Impact factor: 9.546

Review 8.  Recombinant Human Insulins - Clinical Efficacy and Safety in Diabetes Therapy.

Authors:  Wolfgang Landgraf; Juergen Sandow
Journal:  Eur Endocrinol       Date:  2016-03-15

Review 9.  Recombinant Human Insulin in Global Diabetes Management - Focus on Clinical Efficacy.

Authors:  Jean Claude Mbanya; Juergen Sandow; Wolfgang Landgraf; David R Owens
Journal:  Eur Endocrinol       Date:  2017-04-03

10.  Facile synthesis of insulin fusion derivatives through sortase A ligation.

Authors:  Maria M Disotuar; Jake A Smith; Jinze Li; Steve Alam; Nai-Pin Lin; Danny Hung-Chieh Chou
Journal:  Acta Pharm Sin B       Date:  2020-11-21       Impact factor: 11.413
  10 in total

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