Literature DB >> 9555078

mu Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality.

H H Loh1, H C Liu, A Cavalli, W Yang, Y F Chen, L N Wei.   

Abstract

The mu opioid receptor gene (MOR) was mutated in mice by a gene targeting procedure. In these MOR-knockout mice, the analgesic effects of morphine, its major metabolites, morphine-6-glucuronide (M-6-G) and morphine-6-ethereal sulfate (M-6-S), and endomorphin-2, as well as morphine-induced lethality, were drastically reduced, whereas the effects of DPDPE and U50488 remained unchanged. It is concluded that analgesic effects of mu-specific opioid ligands and acute morphine lethality are mediated by the mu receptor. Copyright 1998 Elsevier Science B.V.

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Year:  1998        PMID： 9555078     DOI： 10.1016/s0169-328x(97)00353-7

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  80 in total

1.  Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling.

Authors:  Pin-Tse Lee; Po-Kuan Chao; Li-Chin Ou; Jian-Ying Chuang; Yen-Chang Lin; Shu-Chun Chen; Hsiao-Fu Chang; Ping-Yee Law; Horace H Loh; Yu-Sheng Chao; Tsung-Ping Su; Shiu-Hwa Yeh
Journal:  Nucleic Acids Res       Date:  2014-10-31       Impact factor: 16.971

Review 2.  G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse: psychostimulant and opiate studies in knockout mice.

Authors:  Laura M Bohn; Raul R Gainetdinov; Marc G Caron
Journal:  Neuromolecular Med       Date:  2004       Impact factor: 3.843

3.  Intrathecal delivery of a mutant micro-opioid receptor activated by naloxone as a possible antinociceptive paradigm.

Authors:  J H Kao; S L Chen; H I Ma; P Y Law; P L Tao; H H Loh
Journal:  J Pharmacol Exp Ther       Date:  2010-06-16       Impact factor: 4.030

4.  Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids.

Authors:  Xian-Yu Liu; Zhong-Chun Liu; Yan-Gang Sun; Michael Ross; Seungil Kim; Feng-Fang Tsai; Qi-Fang Li; Joseph Jeffry; Ji-Young Kim; Horace H Loh; Zhou-Feng Chen
Journal:  Cell       Date:  2011-10-14       Impact factor: 41.582

Review 5.  Candidate gene polymorphisms predicting individual sensitivity to opioids.

Authors:  Shinya Kasai; Masakazu Hayashida; Ichiro Sora; Kazutaka Ikeda
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2007-11-13       Impact factor: 3.000

Review 6.  Mu opioids and their receptors: evolution of a concept.

Authors:  Gavril W Pasternak; Ying-Xian Pan
Journal:  Pharmacol Rev       Date:  2013-09-27       Impact factor: 25.468

7.  Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia.

Authors:  L Gendron; J E Pintar; C Chavkin
Journal:  Neuroscience       Date:  2007-10-05       Impact factor: 3.590

8.  Region-dependent attenuation of mu opioid receptor-mediated G-protein activation in mouse CNS as a function of morphine tolerance.

Authors:  L J Sim-Selley; K L Scoggins; M P Cassidy; L A Smith; W L Dewey; F L Smith; D E Selley
Journal:  Br J Pharmacol       Date:  2007-06-18       Impact factor: 8.739

Review 9.  μ-Opioid receptor 6-transmembrane isoform: A potential therapeutic target for new effective opioids.

Authors:  Marino Convertino; Alexander Samoshkin; Josee Gauthier; Michael S Gold; William Maixner; Nikolay V Dokholyan; Luda Diatchenko
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2014-12-06       Impact factor: 5.067

10.  Mu-opioid receptors are not necessary for nortriptyline treatment of neuropathic allodynia.

Authors:  Yohann Bohren; Dzenan Karavelic; Luc-Henri Tessier; Ipek Yalcin; Claire Gavériaux-Ruff; Brigitte L Kieffer; Marie-José Freund-Mercier; Michel Barrot
Journal:  Eur J Pain       Date:  2009-12-28       Impact factor: 3.931
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