PURPOSE: To detail the outcome, in terms of local recurrence, local invasive recurrence, distant recurrence, and breast cancer mortality for patients previously treated for ductal carcinoma in situ (DCIS). PATIENTS AND METHODS: Clinical, pathologic, and outcome data were collected prospectively for 707 patients with DCIS accrued from 1972 through June 1997. RESULTS: There were 74 local recurrences; 39 were noninvasive (DCIS) and 35 were invasive. Fifty-one percent of patients with invasive recurrences presented with stage 1 disease; the remainder presented with more advanced disease. Invasive local recurrence after mastectomy was a rare event that occurred in 0.8% of patients. Invasive recurrence after breast preservation was more common and occurred in 7.4% of patients. The 8-year probability of breast cancer mortality after breast preservation was 2.1%, a number that is likely to increase with longer follow-up. The 8-year breast cancer-specific mortality and distant-disease probability for the subgroup of 74 patients with locally recurrent disease was 8.8% and 20.8%, respectively. If only the 35 invasive recurrences are considered as events, the 8-year breast cancer-specific mortality and distant-disease probability was 14.4% and 27.1%, respectively. CONCLUSION: Invasive local recurrence after breast-preservation treatment for patients with DCIS is a serious event that converts patients with previous stage 0 disease to patients with disease that ranges from stage I to stage IV. These results, however, indicate that most DCIS patients with local recurrence can be salvaged.
PURPOSE: To detail the outcome, in terms of local recurrence, local invasive recurrence, distant recurrence, and breast cancer mortality for patients previously treated for ductal carcinoma in situ (DCIS). PATIENTS AND METHODS: Clinical, pathologic, and outcome data were collected prospectively for 707 patients with DCIS accrued from 1972 through June 1997. RESULTS: There were 74 local recurrences; 39 were noninvasive (DCIS) and 35 were invasive. Fifty-one percent of patients with invasive recurrences presented with stage 1 disease; the remainder presented with more advanced disease. Invasive local recurrence after mastectomy was a rare event that occurred in 0.8% of patients. Invasive recurrence after breast preservation was more common and occurred in 7.4% of patients. The 8-year probability of breast cancer mortality after breast preservation was 2.1%, a number that is likely to increase with longer follow-up. The 8-year breast cancer-specific mortality and distant-disease probability for the subgroup of 74 patients with locally recurrent disease was 8.8% and 20.8%, respectively. If only the 35 invasive recurrences are considered as events, the 8-year breast cancer-specific mortality and distant-disease probability was 14.4% and 27.1%, respectively. CONCLUSION: Invasive local recurrence after breast-preservation treatment for patients with DCIS is a serious event that converts patients with previous stage 0 disease to patients with disease that ranges from stage I to stage IV. These results, however, indicate that most DCIS patients with local recurrence can be salvaged.
Authors: Agnieszka K Witkiewicz; Boris Freydin; Inna Chervoneva; Magdalena Potoczek; Wendy Rizzo; Hallgeir Rui; Jonathan R Brody; Gordon F Schwartz; Michael P Lisanti Journal: Cancer Biol Ther Date: 2010-08-21 Impact factor: 4.742
Authors: I Kong; S A Narod; C Taylor; L Paszat; R Saskin; S Nofech-Moses; D Thiruchelvam; W Hanna; J P Pignol; S Sengupta; L Elavathil; P A Jani; S J Done; S Metcalfe; E Rakovitch Journal: Curr Oncol Date: 2014-02 Impact factor: 3.677
Authors: Elizabeth Fitzsullivan; Sara A Lari; Benjamin Smith; Abigail S Caudle; Savitri Krishnamurthy; Anthony Lucci; Elizabeth A Mittendorf; Gildy V Babiera; Dalliah M Black; Jamie L Wagner; Isabelle Bedrosian; Wendy Woodward; Sarah M Gainer; Rosa Hwang; Funda Meric-Bernstam; Kelly K Hunt; Henry M Kuerer Journal: Ann Surg Oncol Date: 2013-08-23 Impact factor: 5.344
Authors: E Rakovitch; S Nofech-Mozes; W Hanna; S Narod; D Thiruchelvam; R Saskin; J Spayne; C Taylor; L Paszat Journal: Br J Cancer Date: 2012-02-23 Impact factor: 7.640
Authors: J Thomas; A Evans; J Macartney; S E Pinder; A Hanby; I Ellis; O Kearins; T Roberts; K Clements; G Lawrence; H Bishop Journal: Br J Cancer Date: 2010-01-05 Impact factor: 7.640