Literature DB >> 954975

[3H]-Noncocaine and [3H]-pseudococaine: effect of N-demethylation and C2-epimerization of cocaine on its pharmacokinetics in the rat.

A L Misra, R B Pontani, S J Mule'.   

Abstract

After i.v. injections of cocaine, norcocaine, pseudococaine to the rat, the T 1/2 in brain were 0.4, 0.6, 0.2 h respectively and in plasma 0.4, 0.5, 0.2 h respectively. Benzoylnorecgonine and norecgonine were the metabolites of norcocaine in brain. Pseudonorcocaine, pseudobenzoylnorecgonine, pseudobenzoylecgonine and pseudoecgonine were the metabolites of pseudococaine in rat brain. Benzolynorecgonine and pseudobenzoylecgonine had potent stimulant activity intracisternally in the rats.

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Year:  1976        PMID： 954975     DOI： 10.1007/BF02003753

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  14 in total

1.  [BRAIN ELECTRICAL STUDIES ON THE EFFECTS OF COCAINE AND PSEUDOCOCAINE].

Authors:  H D LUX; G SCHMIDT
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1964-02-13

2.  [Comparative research on the effects of normal cocaine and pseudococaine].

Authors:  G SCHMIDT; B KALISCHER; B WOECKEL
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1961

3.  Alpha-cocaine.

Authors:  R FOSTER; H R ING; V VARAGIC
Journal:  Br J Pharmacol Chemother       Date:  1955-12

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Authors:  G SCHMIDT; P MEISSE
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1962

5.  Estimation and disposition of [3H]benzoylecgonine and pharmacological activity of some cocaine metabolites.

Authors:  A L Misra; P K Nayak; R Bloch; S J Mulé
Journal:  J Pharm Pharmacol       Date:  1975-10       Impact factor: 3.765

6.  Separation of cocaine, some of its metabolites and congeners on glass fibre sheets.

Authors:  A L Misra; R B Pontani; S J Mulé
Journal:  J Chromatogr       Date:  1973-06-27

7.  Pharmacokinetics and metabolism of (3H) thebaine.

Authors:  A L Misra; R B Pontani; S J Mulé
Journal:  Xenobiotica       Date:  1974-01       Impact factor: 1.908

8.  Steric aspects of adrenergic drugs. XX. Accumulation of (-)- and (+)-norepinephrine- 14 C by peripheral tissues of the rat.

Authors:  R D Krell; P N Patil
Journal:  J Pharmacol Exp Ther       Date:  1972-08       Impact factor: 4.030

9.  Norcocaine: a pharmacologically active metabolite of cocaine found in brain.

Authors:  R L Hawks; I J Kopin; R W Colburn; N B Thoa
Journal:  Life Sci       Date:  1974-12-15       Impact factor: 5.037

10.  Calcium-binding property of cocaine and some of its active metabolites-formation of molecular complexes.

Authors:  A L Misra; S J Mule
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1975-08
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  3 in total

1.  Phasic firing of single neurons in the rat nucleus accumbens correlated with the timing of intravenous cocaine self-administration.

Authors:  L L Peoples; M O West
Journal:  J Neurosci       Date:  1996-05-15       Impact factor: 6.167

2.  Comparative effects of cocaine and pseudococaine on EEG activities, cardiorespiratory functions, and self-administration behavior in the rhesus monkey.

Authors:  M Matsuzaki; P J Spingler; E G Whitlock; A L Misra; S J Mulé
Journal:  Psychopharmacology (Berl)       Date:  1978-04-14       Impact factor: 4.530

3.  Cocaine cue in pigeons: time course studies and generalization to structurally related compounds (norcocaine, WIN 35,428 and 35,065-2) and (+)-amphetamine.

Authors:  T U Järbe
Journal:  Br J Pharmacol       Date:  1981-08       Impact factor: 8.739
  3 in total

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