Literature DB >> 1179036

Calcium-binding property of cocaine and some of its active metabolites-formation of molecular complexes.

A L Misra, S J Mule.   

Abstract

Cocaine, benzoylecgonine, benzoylnorecgonine, norcocaine, ecgonine methyl ester but not ecgonine formed distinct molecular complexes with calcium chloride of the general formula [B. CaC12-2H20]. The particularly strong interaction observed with benzoylecgonine, benzoylnorecgonine and calcium may play a role in the potent stimulant activity of these 2 compounds observed in rats after intracisternal administration.

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Year:  1975        PMID： 1179036

Source DB:  PubMed          Journal:  Res Commun Chem Pathol Pharmacol        ISSN： 0034-5164


  2 in total

1.  [3H]-Noncocaine and [3H]-pseudococaine: effect of N-demethylation and C2-epimerization of cocaine on its pharmacokinetics in the rat.

Authors:  A L Misra; R B Pontani; S J Mule'
Journal:  Experientia       Date:  1976

2.  Fetal and maternal brain and plasma levels of cocaine and benzoylecgonine following chronic subcutaneous administration of cocaine during gestation in rats.

Authors:  L P Spear; N A Frambes; C L Kirstein
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530
  2 in total

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