Literature DB >> 954846

Effects of zinc chloride on gastric secretion and ulcer formation in pylorus-occluded rats.

C H Cho, C W Ogle, S Dai.   

Abstract

The effects of 10-day pretreatment with i.p. injections of zinc chloride, 16 mg/kg, on gastric secretion and on gastric ulceration induced by stress or by acid accumulation were examined in pylorus-occluded rats. Zinc chloride pretreatment significantly reduced the volume of gastric secretion and the total acid output as well as the incidence of gastric ulcers induced either by stress or by acid accumulation. The findings support the idea zinc compounds may be useful in the treatment of gastric ulcers.

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Year:  1976        PMID： 954846     DOI： 10.1016/0014-2999(76)90337-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

1.  Prevention of radiation esophagitis by polaprezinc (zinc L-carnosine) in patients with non-small cell lung cancer who received chemoradiotherapy.

Authors:  Komei Yanase; Norihiko Funaguchi; Hirotoshi Iihara; Maya Yamada; Daizo Kaito; Junki Endo; Fumitaka Ito; Yasushi Ohno; Hidekazu Tanaka; Yoshinori Itoh; Shinya Minatoguchi
Journal:  Int J Clin Exp Med       Date:  2015-09-15

2.  Mechanism of acid secretory changes in rat stomach after damage by taurocholate: role of nitric oxide, histamine, and sensory neurons.

Authors:  K Takeuchi; S Kato; T Yasuhiro; K Yagi
Journal:  Dig Dis Sci       Date:  1997-03       Impact factor: 3.199

3.  Secretagogue-dependent and -independent transport of zinc hydration forms in rat parietal cells.

Authors:  Florentina Sophie Ferstl; Alice Miriam Kitay; Rebecca Marion Trattnig; Abrar Alsaihati; John Peter Geibel
Journal:  Pflugers Arch       Date:  2016-10-19       Impact factor: 3.657

4.  Does increased gastric mucus play a role in the ulcer-protecting effects of zinc sulphate?

Authors:  C H Cho; C W Ogle
Journal:  Experientia       Date:  1978-01-15

5.  Effects of zinc L-carnosine on gastric mucosal and cell damage caused by ethanol in rats. Correlation with endogenous prostaglandin E2.

Authors:  T Arakawa; H Satoh; A Nakamura; H Nebiki; T Fukuda; H Sakuma; H Nakamura; M Ishikawa; M Seiki; K Kobayashi
Journal:  Dig Dis Sci       Date:  1990-05       Impact factor: 3.199

6.  Zinc deficiency delays gastric ulcer healing in rats.

Authors:  T Watanabe; T Arakawa; T Fukuda; K Higuchi; K Kobayashi
Journal:  Dig Dis Sci       Date:  1995-06       Impact factor: 3.199

7.  Effects of zinc-aspartate and zinc-glycinate in healthy rats and on reserpine-induced gastric lesions.

Authors:  F Barbarino; E Togănel; C Brilinschi; I Ciupe; I Pop; I Marinescu
Journal:  Biol Trace Elem Res       Date:  1988-08       Impact factor: 3.738
  7 in total

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