Literature DB >> 2331952

Effects of zinc L-carnosine on gastric mucosal and cell damage caused by ethanol in rats. Correlation with endogenous prostaglandin E2.

T Arakawa1, H Satoh, A Nakamura, H Nebiki, T Fukuda, H Sakuma, H Nakamura, M Ishikawa, M Seiki, K Kobayashi.   

Abstract

The effects of zinc L-carnosine on ethanol-induced damage and the correlation of these effects with endogenous prostaglandin E2 were evaluated in rat gastric mucosa in vivo and in vitro. When given either intragastrically or intraperitoneally, zinc L-carnosine (10 or 30 mg/kg) prevented gross visible damage to gastric mucosa caused by ethanol without affecting the mucosal prostaglandin E2 level. This protective effect of zinc L-carnosine was not inhibited by indomethacin. Histological assessment showed that zinc L-carnosine inhibited deep mucosal necrosis, as did 16,16-dimethyl prostaglandin E2. Zinc L-carnosine (10(-6) or 10(-5) M) inhibited the damage caused by ethanol to gastric cells isolated from rat gastric mucosa in vitro; this effect was not inhibited by indomethacin. The results suggested that zinc L-carnosine protects the gastric mucosa and enhances cellular resistance to ethanol without the mediation of endogenous prostaglandins.

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Year:  1990        PMID： 2331952     DOI： 10.1007/bf01540402

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  30 in total

1.  Effect of bile on lysosomal stability in the mucosa of the canine gastric antrum.

Authors:  D Waldron-Edward; M I Boutros; H S Himal
Journal:  Gastroenterology       Date:  1977-11       Impact factor: 22.682

2.  The healing of gastric ulcers by zinc sulphate.

Authors:  D J Frommer
Journal:  Med J Aust       Date:  1975-11-22       Impact factor: 7.738

3.  Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury.

Authors:  A Robert; J E Nezamis; C Lancaster; A J Hanchar
Journal:  Gastroenterology       Date:  1979-09       Impact factor: 22.682

4.  Clinical trial of a new carbenoxolone analogue (BX24), zinc sulphate, and vitamin A in the treatment of gastric ulcer.

Authors:  P M Fraser; R Doll; M J Langman; J J Misiewicz; H H Shawdon
Journal:  Gut       Date:  1972-06       Impact factor: 23.059

5.  Studies of zinc and histamine on lysosomal fragility: possible role in stress ulceration.

Authors:  C H Cho; C J Pfeiffer; A Cheema
Journal:  Pharmacol Biochem Behav       Date:  1980-07       Impact factor: 3.533

6.  Reserpine-induced gastric ulcers: protection by lysosomal stabilization due to zinc.

Authors:  C J Pfeiffer; C H Cho; A Cheema; D Saltman
Journal:  Eur J Pharmacol       Date:  1980-02       Impact factor: 4.432

7.  Protection by metals against ethanol-induced gastric mucosal injury in the rat. Comparative biochemical and pharmacologic studies implicate protein sulfhydryls.

Authors:  D Dupuy; S Szabo
Journal:  Gastroenterology       Date:  1986-10       Impact factor: 22.682

8.  Protective effect of prostaglandin E 1 (PGE 1 ) on lysosomal enzyme release in serotonin-induced gastric ulceration.

Authors:  W W Ferguson; A W Edmonds; J R Starling; S L Wangensteen
Journal:  Ann Surg       Date:  1973-06       Impact factor: 12.969

9.  Protection of gastric surface epithelial cells of rats by 16,16-dimethyl prostaglandin E2 and sofalcone, a synthetic flavonoid derivative of sophoradin, against ethanol.

Authors:  T Arakawa; A Nakamura; H Yamada; H Nebiki; H Satoh; T Fukuda; K Kobayashi
Journal:  Digestion       Date:  1988       Impact factor: 3.216

10.  A correlative study of the antiulcer effects of zinc sulphate in stressed rats.

Authors:  C H Cho; C W Ogle
Journal:  Eur J Pharmacol       Date:  1978-03-01       Impact factor: 4.432
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  16 in total

1.  Induction of a 72-kDa heat-shock protein in cultured rat gastric mucosal cells and rat gastric mucosa by zinc L-carnosine.

Authors:  Masaru Odashima; Michiro Otaka; Mario Jin; Noriaki Konishi; Toshihiro Sato; Sayuri Kato; Tamotsu Matsuhashi; Chieko Nakamura; Sumio Watanabe
Journal:  Dig Dis Sci       Date:  2002-12       Impact factor: 3.199

2.  Polaprezinc exerts a salutary effect on impaired healing of acute gastric lesions in diabetic rats.

Authors:  R P Korolkiewicz; A Fujita; K Seto; K Suzuki; K Takeuchi
Journal:  Dig Dis Sci       Date:  2000-06       Impact factor: 3.199

3.  Blood cell, liver function, and response changes by PEG-interferon-alpha2b plus ribavirin with polaprezinc therapy in patients with chronic hepatitis C.

Authors:  Ke Ih Kim; Soo Ryang Kim; Noriko Sasase; Yoko Akimoto; Mao Shikata; Aya Ohtani; Teruko Hirooka; Kazuhiko Tanaka
Journal:  Hepatol Int       Date:  2008-01-11       Impact factor: 6.047

4.  Subcutaneous loperamide prevents gastric lesions induced by necrotizing agents in rats.

Authors:  Y Hatakeyama; M Tomoi; M Ohtsuka; K Shimomura
Journal:  Dig Dis Sci       Date:  1997-12       Impact factor: 3.199

5.  Effects of polaprezinc on lipid peroxidation, neutrophil accumulation, and TNF-alpha expression in rats with aspirin-induced gastric mucosal injury.

Authors:  Y Naito; T Yoshikawa; N Yagi; K Matsuyama; N Yoshida; K Seto; T Yoneta
Journal:  Dig Dis Sci       Date:  2001-04       Impact factor: 3.199

6.  The gastric cytoprotective action of adenosine and prostaglandin E2 in rabbits.

Authors:  C H Cho; B W Chen; C T Luk; K H Lai; S K Lam
Journal:  Agents Actions       Date:  1994-10

7.  Triple therapy of interferon and ribavirin with zinc supplementation for patients with chronic hepatitis C: a randomized controlled clinical trial.

Authors:  Hideyuki Suzuki; Hitoshi Takagi; Naondo Sohara; Daisuke Kanda; Satoru Kakizaki; Ken Sato; Masatomo Mori
Journal:  World J Gastroenterol       Date:  2006-02-28       Impact factor: 5.742

8.  Mucosal ulcerogenic action of monochloramine in rat stomachs: effects of polaprezinc and sucralfate.

Authors:  S Kato; H Nishiwaki; A Konaka; K Takeuchi
Journal:  Dig Dis Sci       Date:  1997-10       Impact factor: 3.199

9.  Zinc Supplementation with Polaprezinc Protects Mouse Hepatocytes against Acetaminophen-Induced Toxicity via Induction of Heat Shock Protein 70.

Authors:  Tadashi Nishida; Shuzo Ohata; Chiaki Kusumoto; Shinsuke Mochida; Junya Nakada; Yoshimi Inagaki; Yoshiji Ohta; Tatsuya Matsura
Journal:  J Clin Biochem Nutr       Date:  2009-12-29       Impact factor: 3.114

10.  Polaprezinc Protects Mice against Endotoxin Shock.

Authors:  Shuzo Ohata; Chihiro Moriyama; Atsushi Yamashita; Tadashi Nishida; Chiaki Kusumoto; Shinsuke Mochida; Yukari Minami; Junya Nakada; Kohei Shomori; Yoshimi Inagaki; Yoshiji Ohta; Tatsuya Matsura
Journal:  J Clin Biochem Nutr       Date:  2010-04-10       Impact factor: 3.114
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