Literature DB >> 9547288

Gel electrophoretic detection of 7,8-dihydro-8-oxoguanine and 7, 8-dihydro-8-oxoadenine via oxidation by Ir (IV).

J G Muller1, V Duarte, R P Hickerson, C J Burrows.   

Abstract

Two gel electrophoretic methods are described for detection of 7, 8-dihydro-8-oxoguanine and 7,8-dihydro-8-oxoadenine based on their further oxidation with one-electron oxidants including IrCl62-and IrBr62-. The products of nucleobase oxidation lead to enhanced piperidine-sensitive cleavage and to highly visible stop points in a primer extension assay. 8-oxoG and 8-oxoA lesions may be distinguished by the latter's inability to be oxidized by IrBr62-compared to IrCl62-Comparison is also made to oxidation by MnO4-.

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Year:  1998        PMID： 9547288      PMCID： PMC147540          DOI： 10.1093/nar/26.9.2247

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  10 in total

1.  DNA strand cleavage at 8-hydroxyguanine residues by hot piperidine treatment.

Authors:  M H Chung; H Kiyosawa; E Ohtsuka; S Nishimura; H Kasai
Journal:  Biochem Biophys Res Commun       Date:  1992-10-15       Impact factor: 3.575

2.  Hydroxyl free radical adduct of deoxyguanosine: sensitive detection and mechanisms of formation.

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Journal:  Free Radic Res Commun       Date:  1986

Review 3.  Reactions of oxyl radicals with DNA.

Authors:  A P Breen; J A Murphy
Journal:  Free Radic Biol Med       Date:  1995-06       Impact factor: 7.376

4.  The catalytic mechanism of Fpg protein. Evidence for a Schiff base intermediate and amino terminus localization of the catalytic site.

Authors:  J Tchou; A P Grollman
Journal:  J Biol Chem       Date:  1995-05-12       Impact factor: 5.157

5.  Sequencing end-labeled DNA with base-specific chemical cleavages.

Authors:  A M Maxam; W Gilbert
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

6.  Synthesis and cleavage of oligodeoxynucleotides containing a 5-hydroxyuracil residue at a defined site.

Authors:  J Fujimoto; L Tran; L C Sowers
Journal:  Chem Res Toxicol       Date:  1997-11       Impact factor: 3.739

7.  Redox ribonucleosides. Isolation and characterization of 5-hydroxyuridine, 8-hydroxyguanosine, and 8-hydroxyadenosine from Torula yeast RNA.

Authors:  H Yanagawa; Y Ogawa; M Ueno
Journal:  J Biol Chem       Date:  1992-07-05       Impact factor: 5.157

8.  Steady-state and pre-steady-state kinetic analysis of dNTP insertion opposite 8-oxo-7,8-dihydroguanine by Escherichia coli polymerases I exo- and II exo-.

Authors:  L G Lowe; F P Guengerich
Journal:  Biochemistry       Date:  1996-07-30       Impact factor: 3.162

9.  Characterization of the alkaline degradation products of an oligodeoxynucleotide containing 8-oxo-7,8-dihydro-2'-deoxyguanosine by electrospray ionization mass spectrometry.

Authors:  M C Torres; R A Rieger; C R Iden
Journal:  Chem Res Toxicol       Date:  1996-12       Impact factor: 3.739

10.  Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG.

Authors:  S Shibutani; M Takeshita; A P Grollman
Journal:  Nature       Date:  1991-01-31       Impact factor: 49.962
  10 in total
  29 in total

1.  Comparison of Transition Metal-Mediated Oxidation Reactions of Guanine in Nucleoside and Single-Stranded Oligodeoxynucleotide Contexts.

Authors:  Pranjali Ghude; Mark A Schallenberger; Aaron M Fleming; James G Muller; Cynthia J Burrows
Journal:  Inorganica Chim Acta       Date:  2011-04-15       Impact factor: 2.545

2.  Repair of hydantoins, one electron oxidation product of 8-oxoguanine, by DNA glycosylases of Escherichia coli.

Authors:  T K Hazra; J G Muller; R C Manuel; C J Burrows; R S Lloyd; S Mitra
Journal:  Nucleic Acids Res       Date:  2001-05-01       Impact factor: 16.971

3.  DNA polymerase zeta is essential for hexavalent chromium-induced mutagenesis.

Authors:  Travis J O'Brien; Preston Witcher; Bradford Brooks; Steven R Patierno
Journal:  Mutat Res       Date:  2009-02-06       Impact factor: 2.433

4.  Solvent exposure associated with single abasic sites alters the base sequence dependence of oxidation of guanine in DNA in GG sequence contexts.

Authors:  Young-Ae Lee; Zhi Liu; Peter C Dedon; Nicholas E Geacintov; Vladimir Shafirovich
Journal:  Chembiochem       Date:  2011-06-07       Impact factor: 3.164

5.  G-quadruplex folds of the human telomere sequence alter the site reactivity and reaction pathway of guanine oxidation compared to duplex DNA.

Authors:  Aaron M Fleming; Cynthia J Burrows
Journal:  Chem Res Toxicol       Date:  2013-03-13       Impact factor: 3.739

6.  Endonuclease and Exonuclease Activities on Oligodeoxynucleotides Containing Spiroiminodihydantoin Depend on the Sequence Context and the Lesion Stereochemistry.

Authors:  Xin Chen; Aaron M Fleming; James G Muller; Cynthia J Burrows
Journal:  New J Chem       Date:  2013-11-01       Impact factor: 3.591

7.  DNA interstrand cross-link formation initiated by reaction between singlet oxygen and a modified nucleotide.

Authors:  In Seok Hong; Marc M Greenberg
Journal:  J Am Chem Soc       Date:  2005-08-03       Impact factor: 15.419

8.  Reconciliation of chemical, enzymatic, spectroscopic and computational data to assign the absolute configuration of the DNA base lesion spiroiminodihydantoin.

Authors:  Aaron M Fleming; Anita M Orendt; Yanan He; Judy Zhu; Rina K Dukor; Cynthia J Burrows
Journal:  J Am Chem Soc       Date:  2013-11-21       Impact factor: 15.419

9.  Influence of substrate complexity on the diastereoselective formation of spiroiminodihydantoin and guanidinohydantoin from chromate oxidation.

Authors:  Julia N Gremaud; Brooke D Martin; Kent D Sugden
Journal:  Chem Res Toxicol       Date:  2010-02-15       Impact factor: 3.739

10.  Structural context effects in the oxidation of 8-oxo-7,8-dihydro-2'-deoxyguanosine to hydantoin products: electrostatics, base stacking, and base pairing.

Authors:  Aaron M Fleming; James G Muller; Adrienne C Dlouhy; Cynthia J Burrows
Journal:  J Am Chem Soc       Date:  2012-08-29       Impact factor: 15.419
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