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Literature DB >> 9546219

Unusual beta-sheet periodicity in small cyclic peptides.

A C Gibbs¹, L H Kondejewski, W Gronwald, A M Nip, R S Hodges, B D Sykes, D S Wishart.

Abstract

Cyclic peptide homologs of gramicidin S containing 6, 8, 10, 12, 14 and 16 residues were synthesized and characterized using circular dichroism (CD) and 1H NMR spectroscopy. Based on the three-dimensional structures generated from these data we have found strong evidence of a periodic sequence-length dependence on beta-sheet content. In particular, peptides of length 6, 10 and 14 residues exhibit a high beta-sheet content, while peptides of 8, 12 and 16 residues appear to exist as random coils. This unusual beta-sheet periodicity may have important implications in our understanding of beta-sheet formation and in the design of constrained beta-sheet and beta-hairpin mimics.

Entities: Chemical

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Year: 1998 PMID： 9546219 DOI： 10.1038/nsb0498-284

Source DB: PubMed Journal: Nat Struct Biol ISSN： 1072-8368

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Cited

23 in total

1. 13C(alpha) and 13C(beta) chemical shifts as a tool to delineate beta-hairpin structures in peptides.

Authors: C M Santiveri; M Rico; M A Jiménez
Journal: J Biomol NMR Date: 2001-04 Impact factor: 2.835

2. Nanosecond temperature jump relaxation dynamics of cyclic beta-hairpin peptides.

Authors: Shelia J Maness; Stefan Franzen; Alan C Gibbs; Timothy P Causgrove; R Brian Dyer
Journal: Biophys J Date: 2003-06 Impact factor: 4.033

3. Solution structure of Arabidopsis thaliana protein At5g39720.1, a member of the AIG2-like protein family.

Authors: Betsy L Lytle; Francis C Peterson; Ejan M Tyler; Carrie L Newman; Dmitriy A Vinarov; John L Markley; Brian F Volkman
Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun Date: 2006-05-31

4. Electron transfer dissociation coupled to an Orbitrap analyzer may promise a straightforward and accurate sequencing of disulfide-bridged cyclic peptides: a case study.

Authors: Xiaotao Duan; Frank A Engler; Jun Qu
Journal: J Mass Spectrom Date: 2010-12 Impact factor: 1.982

5. Structure and lipid interactions of an anti-inflammatory and anti-atherogenic 10-residue class G(*) apolipoprotein J peptide using solution NMR.

Authors: Vinod K Mishra; Mayakonda N Palgunachari; Jason S Hudson; Ronald Shin; Tamara D Keenum; N Rama Krishna; G M Anantharamaiah
Journal: Biochim Biophys Acta Date: 2010-10-21

Unusual beta-sheet periodicity in small cyclic peptides.

1. 13C(alpha) and 13C(beta) chemical shifts as a tool to delineate beta-hairpin structures in peptides.

2. Nanosecond temperature jump relaxation dynamics of cyclic beta-hairpin peptides.

3. Solution structure of Arabidopsis thaliana protein At5g39720.1, a member of the AIG2-like protein family.

4. Electron transfer dissociation coupled to an Orbitrap analyzer may promise a straightforward and accurate sequencing of disulfide-bridged cyclic peptides: a case study.

5. Structure and lipid interactions of an anti-inflammatory and anti-atherogenic 10-residue class G(*) apolipoprotein J peptide using solution NMR.

6. A Small Cyclic β-Hairpin Peptide Mimics the Rbfox2 RNA Recognition Motif and Binds to the Precursor miRNA 20b.

7. The cyclic cystine ladder in θ-defensins is important for structure and stability, but not antibacterial activity.

8. A Macrocyclic Peptide Ligand Binds the Oncogenic MicroRNA-21 Precursor and Suppresses Dicer Processing.

9. Cyclic N-terminal loop of amylin forms non amyloid fibers.

10. Effect of ring size on conformation and biological activity of cyclic cationic antimicrobial peptides.