Literature DB >> 9543727

Further studies on analgesic activity of cyclic imides.

V Cechinel Filho1, R Corrêa, Z Vaz, J B Calixto, R J Nunes, T R Pinheiro, A D Andricopulo, R A Yunes.   

Abstract

As part of our research programme to obtain pharmacologically active compounds structurally related to cyclic imides, we have synthesized different compounds and examined their analgesic activities using the abdominal constriction test in mice. The results showed that some of the compounds studied, given intraperitoneally, exhibited graded and significant analgesia against acetic acid-induced abdominal constriction, being several times more potent than aspirin and paracetamol, two standard drugs used for comparison.

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Year:  1998        PMID： 9543727     DOI： 10.1016/s0014-827x(97)00006-2

Source DB:  PubMed          Journal:  Farmaco        ISSN： 0014-827X


  6 in total

1.  The validation of Calophyllum brasiliense ("guanandi") uses in Brazilian traditional medicine as analgesic by in vivo antinociceptive evaluation and its chemical analysis.

Authors:  Luiz Carlos Klein-Júnior; Daniele Zambiasi; Giovana Rocha Salgado; Franco Delle Monache; Valdir Cechinel Filho; Fátima de Campos Buzzi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2017-04-08       Impact factor: 3.000

2.  4-{(E)-[2-(4-Iodo-but-oxy)benzyl-idene]amino}-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one.

Authors:  Hoong-Kun Fun; Madhukar Hemamalini; Abdullah M Asiri; Salman A Khan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-06-05

3.  1,5-Dimethyl-4-(1-methyl-3-oxo-3-phenylprop-1-enyl-amino)-2-phenyl-1H-pyrazol-3(2H)-one.

Authors:  Hualing Zhu; Zhan Wang; Junjie Ren; Miao Zhang; Wei Xu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-06-11

4.  Microwave assisted synthesis of novel pyrazolone derivatives attached to a pyrimidine moiety and evaluation of their anti-inflammatory, analgesic and antipyretic activities.

Authors:  Rishikesh V Antre; A Cendilkumar; Divakar Goli; Ganesh S Andhale; Rajesh J Oswal
Journal:  Saudi Pharm J       Date:  2011-06-25       Impact factor: 4.330

5.  Synthesis, crystal structure, vibration spectral, and DFT studies of 4-aminoantipyrine and its derivatives.

Authors:  Yi Li; Yuanyuan Liu; Haowei Wang; Xiaohui Xiong; Ping Wei; Fangshi Li
Journal:  Molecules       Date:  2013-01-11       Impact factor: 4.411

6.  Coordination modes of a schiff base pentadentate derivative of 4-aminoantipyrine with cobalt(II), nickel(II) and copper(II) metal ions: synthesis, spectroscopic and antimicrobial studies.

Authors:  Sulekh Chandra; Deepali Jain; Amit Kumar Sharma; Pratibha Sharma
Journal:  Molecules       Date:  2009-01-01       Impact factor: 4.411
  6 in total

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