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Literature DB >> 9543346

Sodium selenate corrects glucose tolerance and heart function in STZ diabetic rats.

M L Battell¹, H L Delgatty, J H McNeill.

Abstract

Sodium selenate, administered intraperitoneally (i.p.), resulted in an improvement in glucose tolerance in treated diabetic rats. Fed rat plasma glucose levels were reduced by selenate treatment in streptozotocin diabetic rats. The lowest values of blood glucose were reached within 3 weeks of beginning the treatment. Food and fluid consumption was reduced in treated compared to untreated diabetic rats. Diabetic treated rats did not release insulin in response to a glucose challenge and insulin release in response to a challenge was markedly reduced in control treated rats. Assessment of heart function using a working heart apparatus showed that treated diabetic rats with improved blood glucose levels had normal heart function at 8 weeks of diabetes in contrast to hearts from non-treated diabetics. This study extends previous observations on the in vivo insulin-like effects of sodium selenate.

Entities: Chemical Disease Species

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Year: 1998 PMID： 9543346 DOI： 10.1023/a:1006819227506

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

33 in total

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13 in total

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Authors: Zhi Huang; Aaron H Rose; Peter R Hoffmann
Journal: Antioxid Redox Signal Date: 2012-01-09 Impact factor: 8.401

2. Selenate enhances STAT3 transcriptional activity in endothelial cells: differential actions of selenate and selenite on LIF cytokine signaling and cell viability.

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Journal: J Inorg Biochem Date: 2012-01-28 Impact factor: 4.155

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Authors: Matthew P Pepper; Marko Z Vatamaniuk; Xi Yan; Carol A Roneker; Xin Gen Lei
Journal: Antioxid Redox Signal Date: 2010-09-29 Impact factor: 8.401

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Journal: Toxicol Appl Pharmacol Date: 2005-05-01 Impact factor: 4.219

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