| Literature DB >> 4686466 |
J T Rotruck, A L Pope, H E Ganther, A B Swanson, D G Hafeman, W G Hoekstra.
Abstract
When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H(2)O(2), added glutathione failed to protect the hemoglobin from oxidative damage. This occurred because the erythrocytes were practically devoid of glutathione-peroxidase activity. Extensively purified preparations of glutathione peroxidase contained a large part of the (75)Se of erythrocytes labeled in vivo. Many of the nutritional effects of selenium can be explained by its role in glutathione peroxidase.Entities:
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Year: 1973 PMID： 4686466 DOI： 10.1126/science.179.4073.588
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728