Literature DB >> 9531986

Isolation and characterisation of an antifungal antibiotic (GR135402) with protein synthesis inhibition.

O S Kinsman1, P A Chalk, H C Jackson, R F Middleton, A Shuttleworth, B A Rudd, C A Jones, H M Noble, H G Wildman, M J Dawson, C Stylli, P J Sidebottom, B Lamont, S Lynn, M V Hayes.   

Abstract

A novel antifungal antibiotic GR135402 has been isolated from a fermentation broth of Graphium putredinis which inhibited protein synthesis in Candida albicans but not rabbit reticulocytes. The spectrum of activity included C. albicans and Cryptococcus neoformans but not some other Candida species or Aspergillus species. Therapeutic efficacy in a mouse model of systemic candidosis was attained following parenteral dosing.

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Year:  1998        PMID： 9531986     DOI： 10.7164/antibiotics.51.41

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  6 in total

1.  Three-dimensional cryo-electron microscopy localization of EF2 in the Saccharomyces cerevisiae 80S ribosome at 17.5 A resolution.

Authors:  M G Gomez-Lorenzo; C M Spahn; R K Agrawal; R A Grassucci; P Penczek; K Chakraburtty; J P Ballesta; J L Lavandera; J F Garcia-Bustos; J Frank
Journal:  EMBO J       Date:  2000-06-01       Impact factor: 11.598

2.  Sordarins: A new class of antifungals with selective inhibition of the protein synthesis elongation cycle in yeasts.

Authors:  J M Domínguez; V A Kelly; O S Kinsman; M S Marriott; F Gómez de las Heras; J J Martín
Journal:  Antimicrob Agents Chemother       Date:  1998-09       Impact factor: 5.191

3.  Sordarins: in vitro activities of new antifungal derivatives against pathogenic yeasts, Pneumocystis carinii, and filamentous fungi.

Authors:  E Herreros; C M Martinez; M J Almela; M S Marriott; F G De Las Heras; D Gargallo-Viola
Journal:  Antimicrob Agents Chemother       Date:  1998-11       Impact factor: 5.191

4.  A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.

Authors:  Javier Botet; María Rodríguez-Mateos; Juan P G Ballesta; José Luis Revuelta; Miguel Remacha
Journal:  Antimicrob Agents Chemother       Date:  2008-02-19       Impact factor: 5.191

5.  Translation elongation factor 2 is part of the target for a new family of antifungals.

Authors:  L Capa; A Mendoza; J L Lavandera; F Gómez de las Heras; J F García-Bustos
Journal:  Antimicrob Agents Chemother       Date:  1998-10       Impact factor: 5.191

6.  Identification of elongation factor 2 as the essential protein targeted by sordarins in Candida albicans.

Authors:  J M Domínguez; J J Martín
Journal:  Antimicrob Agents Chemother       Date:  1998-09       Impact factor: 5.191
  6 in total

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