Literature DB >> 9527804

The Cys607-->Tyr change in the UL97 phosphotransferase confers ganciclovir resistance to two human cytomegalovirus strains recovered from two immunocompromised patients.

F Baldanti1, M R Underwood, C L Talarico, L Simoncini, A Sarasini, K K Biron, G Gerna.   

Abstract

Two ganciclovir (GCV)-resistant human cytomegalovirus (HCMV) strains recovered from an AIDS patient (strain VR4990) and a heart transplant recipient (strain VR5474) showed a Cys607-->Tyr change in the UL97-encoded phosphotransferase. No amino acid substitutions were observed in the viral DNA polymerase. Marker transfer experiments showed marked reduction in GCV phosphorylation and drug susceptibility of the recombinant HCMV strain VR4990rec2-1-1. These results further extend the region of the carboxy-terminal domain of the UL97 phosphotransferase involved in GCV substrate recognition.

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Year:  1998        PMID： 9527804      PMCID： PMC105432          DOI： 10.1128/AAC.42.2.444

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

1.  Four dually resistant human cytomegalovirus strains from AIDS patients: single mutations in UL97 and UL54 open reading frames are responsible for ganciclovir- and foscarnet-specific resistance, respectively.

Authors:  F Baldanti; A Sarasini; E Silini; M Barbi; A Lazzarin; K K Biron; G Gerna
Journal:  Scand J Infect Dis Suppl       Date:  1995

2.  Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS.

Authors:  F Baldanti; M R Underwood; S C Stanat; K K Biron; S Chou; A Sarasini; E Silini; G Gerna
Journal:  J Virol       Date:  1996-03       Impact factor: 5.103

3.  Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir.

Authors:  M N Hanson; L C Preheim; S Chou; C L Talarico; K K Biron; A Erice
Journal:  Antimicrob Agents Chemother       Date:  1995-05       Impact factor: 5.191

4.  Rapid screening for resistance to ganciclovir and foscarnet of primary isolates of human cytomegalovirus from culture-positive blood samples.

Authors:  G Gerna; A Sarasini; E Percivalle; M Zavattoni; F Baldanti; M G Revello
Journal:  J Clin Microbiol       Date:  1995-03       Impact factor: 5.948

5.  Frequency of UL97 phosphotransferase mutations related to ganciclovir resistance in clinical cytomegalovirus isolates.

Authors:  S Chou; S Guentzel; K R Michels; R C Miner; W L Drew
Journal:  J Infect Dis       Date:  1995-07       Impact factor: 5.226

6.  The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines.

Authors:  Z He; Y S He; Y Kim; L Chu; C Ohmstede; K K Biron; D M Coen
Journal:  J Virol       Date:  1997-01       Impact factor: 5.103

7.  The UL97 gene product of human cytomegalovirus is an early-late protein with a nuclear localization but is not a nucleoside kinase.

Authors:  D Michel; I Pavić; A Zimmermann; E Haupt; K Wunderlich; M Heuschmid; T Mertens
Journal:  J Virol       Date:  1996-09       Impact factor: 5.103

8.  Double resistance to ganciclovir and foscarnet of four human cytomegalovirus strains recovered from AIDS patients.

Authors:  A Sarasini; F Baldanti; M Furione; E Percivalle; R Brerra; M Barbi; G Gerna
Journal:  J Med Virol       Date:  1995-11       Impact factor: 2.327

9.  Mutations in human cytomegalovirus UL97 gene confer clinical resistance to ganciclovir and can be detected directly in patient plasma.

Authors:  D G Wolf; I L Smith; D J Lee; W R Freeman; M Flores-Aguilar; S A Spector
Journal:  J Clin Invest       Date:  1995-01       Impact factor: 14.808

10.  A three-nucleotide deletion in the UL97 open reading frame is responsible for the ganciclovir resistance of a human cytomegalovirus clinical isolate.

Authors:  F Baldanti; E Silini; A Sarasini; C L Talarico; S C Stanat; K K Biron; M Furione; F Bono; G Palù; G Gerna
Journal:  J Virol       Date:  1995-02       Impact factor: 5.103
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  17 in total

1.  Emergence of multiple human cytomegalovirus ganciclovir-resistant mutants with deletions and substitutions within the UL97 gene in a patient with severe combined immunodeficiency.

Authors:  D G Wolf; I Yaniv; S Ashkenazi; A Honigman
Journal:  Antimicrob Agents Chemother       Date:  2001-02       Impact factor: 5.191

2.  A nine-codon deletion mutation in the cytomegalovirus UL97 phosphotransferase gene confers resistance to ganciclovir.

Authors:  S Chou; C L Meichsner
Journal:  Antimicrob Agents Chemother       Date:  2000-01       Impact factor: 5.191

3.  Specialization for Cell-Free or Cell-to-Cell Spread of BAC-Cloned Human Cytomegalovirus Strains Is Determined by Factors beyond the UL128-131 and RL13 Loci.

Authors:  Eric P Schultz; Jean-Marc Lanchy; Le Zhang Day; Qin Yu; Christopher Peterson; Jessica Preece; Brent J Ryckman
Journal:  J Virol       Date:  2020-06-16       Impact factor: 5.103

Review 4.  Human cytomegalovirus resistance to antiviral drugs.

Authors:  C Gilbert; G Boivin
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

5.  Use of time-saving flow cytometry for rapid determination of resistance of human cytomegalovirus to ganciclovir.

Authors:  Gyu-Cheol Lee; Dong-Gun Lee; Su-Mi Choi; Jin-Hong Yoo; Sun-Hee Park; Jung-Hyun Choi; Woo-Sung Min; Ok-Hee Cho; Chan-Hee Lee; Wan-Shik Shin
Journal:  J Clin Microbiol       Date:  2005-10       Impact factor: 5.948

6.  Detection of Two Drug-Resistance Mutants of the Cytomegalovirus by High-Resolution Melting Analysis.

Authors:  Xiao-Fan Chen; Tian-Run Li; Hong Yang; Yong Shao; Jie Zhang; Wei Zhang; Bo Yu; Zhun Wei; Bo Wu; Lin Yu
Journal:  J Clin Lab Anal       Date:  2015-05-13       Impact factor: 2.352

7.  Detailed polymorphism study on cytomegalovirus DNA polymerase gene to reveal the most suitable genomic targets for quantitative Real-time PCR.

Authors:  Onur Bilenoğlu; Mustafa Altındiş; Ersoy Öz; Yeliz Yücel-Öz; Öykü İrigül-Sönmez; Can Bora Ünal
Journal:  Bosn J Basic Med Sci       Date:  2015-06-23       Impact factor: 3.363

Review 8.  New strategies for prevention and therapy of cytomegalovirus infection and disease in solid-organ transplant recipients.

Authors:  I G Sia; R Patel
Journal:  Clin Microbiol Rev       Date:  2000-01       Impact factor: 26.132

9.  Improved detection of emerging drug-resistant mutant cytomegalovirus subpopulations by deep sequencing.

Authors:  Sunwen Chou; Ronald J Ercolani; Malaya K Sahoo; Martina I Lefterova; Lynne M Strasfeld; Benjamin A Pinsky
Journal:  Antimicrob Agents Chemother       Date:  2014-06-02       Impact factor: 5.191

10.  Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein.

Authors:  C L Talarico; T C Burnette; W H Miller; S L Smith; M G Davis; S C Stanat; T I Ng; Z He; D M Coen; B Roizman; K K Biron
Journal:  Antimicrob Agents Chemother       Date:  1999-08       Impact factor: 5.191
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