Literature DB >> 7625819

Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir.

M N Hanson1, L C Preheim, S Chou, C L Talarico, K K Biron, A Erice.   

Abstract

Characterization of a ganciclovir-resistant cytomegalovirus strain from a patient with AIDS showed a histidine-to-glutamine change at residue 520 of UL97 (Q520 mutation). In anabolism studies, Q520 was associated with impaired phosphorylation of ganciclovir. Transfer of Q520 to a recombinant virus resulted in a ganciclovir-resistant phenotype.

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Year:  1995        PMID： 7625819      PMCID： PMC162714          DOI： 10.1128/AAC.39.5.1204

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

1.  Foscarnet therapy of ganciclovir-resistant cytomegalovirus in marrow transplantation.

Authors:  W R Drobyski; K K Knox; D R Carrigan; R C Ash
Journal:  Transplantation       Date:  1991-07       Impact factor: 4.939

2.  Prevalence of resistance in patients receiving ganciclovir for serious cytomegalovirus infection.

Authors:  W L Drew; R C Miner; D F Busch; S E Follansbee; J Gullett; S G Mehalko; S M Gordon; W F Owen; T R Matthews; W C Buhles
Journal:  J Infect Dis       Date:  1991-04       Impact factor: 5.226

3.  Progressive disease due to ganciclovir-resistant cytomegalovirus in immunocompromised patients.

Authors:  A Erice; S Chou; K K Biron; S C Stanat; H H Balfour; M C Jordan
Journal:  N Engl J Med       Date:  1989-02-02       Impact factor: 91.245

4.  Ganciclovir-resistant cytomegalovirus clinical isolates: mode of resistance to ganciclovir.

Authors:  S C Stanat; J E Reardon; A Erice; M C Jordan; W L Drew; K K Biron
Journal:  Antimicrob Agents Chemother       Date:  1991-11       Impact factor: 5.191

Review 5.  The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.

Authors:  S K Hanks; A M Quinn; T Hunter
Journal:  Science       Date:  1988-07-01       Impact factor: 47.728

6.  Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance.

Authors:  S Chou; A Erice; M C Jordan; G M Vercellotti; K R Michels; C L Talarico; S C Stanat; K K Biron
Journal:  J Infect Dis       Date:  1995-03       Impact factor: 5.226

7.  A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate.

Authors:  K K Biron; J A Fyfe; S C Stanat; L K Leslie; J B Sorrell; C U Lambe; D M Coen
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

8.  Point mutations in the DNA polymerase gene of human cytomegalovirus that result in resistance to antiviral agents.

Authors:  N S Lurain; K D Thompson; E W Holmes; G S Read
Journal:  J Virol       Date:  1992-12       Impact factor: 5.103

9.  Ganciclovir susceptibilities of cytomegalovirus (CMV) isolates from solid organ transplant recipients with CMV viremia after antiviral prophylaxis.

Authors:  G Boivin; A Erice; D D Crane; D L Dunn; H H Balfour
Journal:  J Infect Dis       Date:  1993-08       Impact factor: 5.226

10.  A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives.

Authors:  V Sullivan; K K Biron; C Talarico; S C Stanat; M Davis; L M Pozzi; D M Coen
Journal:  Antimicrob Agents Chemother       Date:  1993-01       Impact factor: 5.191
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  25 in total

1.  Emergence of multiple human cytomegalovirus ganciclovir-resistant mutants with deletions and substitutions within the UL97 gene in a patient with severe combined immunodeficiency.

Authors:  D G Wolf; I Yaniv; S Ashkenazi; A Honigman
Journal:  Antimicrob Agents Chemother       Date:  2001-02       Impact factor: 5.191

2.  A nine-codon deletion mutation in the cytomegalovirus UL97 phosphotransferase gene confers resistance to ganciclovir.

Authors:  S Chou; C L Meichsner
Journal:  Antimicrob Agents Chemother       Date:  2000-01       Impact factor: 5.191

3.  A standardized plaque reduction assay for determination of drug susceptibilities of cytomegalovirus clinical isolates.

Authors:  M L Landry; S Stanat; K Biron; D Brambilla; W Britt; J Jokela; S Chou; W L Drew; A Erice; B Gilliam; N Lurain; J Manischewitz; R Miner; M Nokta; P Reichelderfer; S Spector; A Weinberg; B Yen-Lieberman; C Crumpacker
Journal:  Antimicrob Agents Chemother       Date:  2000-03       Impact factor: 5.191

Review 4.  Human cytomegalovirus resistance to antiviral drugs.

Authors:  C Gilbert; G Boivin
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

5.  Detection of Two Drug-Resistance Mutants of the Cytomegalovirus by High-Resolution Melting Analysis.

Authors:  Xiao-Fan Chen; Tian-Run Li; Hong Yang; Yong Shao; Jie Zhang; Wei Zhang; Bo Yu; Zhun Wei; Bo Wu; Lin Yu
Journal:  J Clin Lab Anal       Date:  2015-05-13       Impact factor: 2.352

6.  Multidrug resistance conferred by novel DNA polymerase mutations in human cytomegalovirus isolates.

Authors:  Gillian M Scott; Adriana Weinberg; William D Rawlinson; Sunwen Chou
Journal:  Antimicrob Agents Chemother       Date:  2006-10-16       Impact factor: 5.191

7.  Sequencing of cytomegalovirus UL97 gene for genotypic antiviral resistance testing.

Authors:  N S Lurain; A Weinberg; C S Crumpacker; S Chou
Journal:  Antimicrob Agents Chemother       Date:  2001-10       Impact factor: 5.191

8.  Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein.

Authors:  C L Talarico; T C Burnette; W H Miller; S L Smith; M G Davis; S C Stanat; T I Ng; Z He; D M Coen; B Roizman; K K Biron
Journal:  Antimicrob Agents Chemother       Date:  1999-08       Impact factor: 5.191

9.  Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action.

Authors:  Karen K Biron; Robert J Harvey; Stanley C Chamberlain; Steven S Good; Albert A Smith; Michelle G Davis; Christine L Talarico; Wayne H Miller; Robert Ferris; Ronna E Dornsife; Sylvia C Stanat; John C Drach; Leroy B Townsend; George W Koszalka
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191

10.  Detection of human cytomegalovirus mutations associated with ganciclovir resistance in cerebrospinal fluid of AIDS patients with central nervous system disease.

Authors:  D G Wolf; D J Lee; S A Spector
Journal:  Antimicrob Agents Chemother       Date:  1995-11       Impact factor: 5.191
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