Literature DB >> 9527516

Characterization of Streptomyces sp. strain DRS-1 and its ampicillin transformation product.

D Roy1, A Sharma, G Bhowmick, M K Roy, A C Ghosh.   

Abstract

Incubation of ampicillin with whole cells of Streptomyces sp. DRS-1 resulted in accumulation of four compounds different from ampicillin. One of them was isolated, purified and partially characterized. On the basis of spectroscopic characteristics, RF value and antibacterial activity the compound was identified as cephalexin. It could also be obtained from ampicillin by using crude protein extract of the strain.

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Year:  1997        PMID： 9527516     DOI： 10.1007/bf02816945

Source DB:  PubMed          Journal:  Folia Microbiol (Praha)        ISSN： 0015-5632            Impact factor:   2.099


  9 in total

1.  A NEW ANTIBIOTIC, FORMYCIN.

Authors:  M HORI; T TAKITA; G KOYAMA; T TADEUCHI; H UMEZAWA
Journal:  J Antibiot (Tokyo)       Date:  1964-05       Impact factor: 2.649

2.  Conversion of penicillin N to cephalosporin(s) by cell-free extracts of Cephalosporium acremonium.

Authors:  M Kohsaka; A L Demain
Journal:  Biochem Biophys Res Commun       Date:  1976-05-17       Impact factor: 3.575

3.  Cell-free ring expansion of penicillin N to deacetoxycephalosporin C by Cephalosporium acremonium CW-19 and its mutants.

Authors:  M Yoshida; T Konomi; M Kohsaka; J E Baldwin; S Herchen; P Singh; N A Hunt; A L Demain
Journal:  Proc Natl Acad Sci U S A       Date:  1978-12       Impact factor: 11.205

4.  Deacetoxycephalosporin C synthetase and deacetoxycephalosporin C hydroxylase are two separate enzymes in Streptomyces clavuligerus.

Authors:  S E Jensen; D W Westlake; S Wolfe
Journal:  J Antibiot (Tokyo)       Date:  1985-02       Impact factor: 2.649

5.  Chemistry of cephalosporin antibiotics. XXI. Conversion of penicillins to cephalexin.

Authors:  R R Chauvette; P A Pennington; C W Ryan; R D Cooper; F L José; I G Wright; E M Van Heyningen; G W Huffman
Journal:  J Org Chem       Date:  1971-05-07       Impact factor: 4.354

6.  Rapid method for characterization of actinomycetes by cell wall composition.

Authors:  C J Boone; L Pine
Journal:  Appl Microbiol       Date:  1968-02

7.  Incorporation of 3H and 14C from (6 alpha-3H)penicillin N and (10-14C,6 alpha-3H) penicillin N into deacetoxycephalosporin C.

Authors:  J E Baldwin; P D Singh; M Yoshida; Y Sawada; A L Demain
Journal:  Biochem J       Date:  1980-03-15       Impact factor: 3.857

8.  Copurification and characterization of deacetoxycephalosporin C synthetase/hydroxylase from Cephalosporium acremonium.

Authors:  J E Dotzlaf; W K Yeh
Journal:  J Bacteriol       Date:  1987-04       Impact factor: 3.490

9.  Studies on the ring-cyclization and ring-expansion enzymes of beta-lactam biosynthesis in Cephalosporium acremonium.

Authors:  J Kupka; Y Q Shen; S Wolfe; A L Demain
Journal:  Can J Microbiol       Date:  1983-05       Impact factor: 2.419
  9 in total
  2 in total

1.  In vitro transformation of ampicillin to cephalexin by free and immobilized cells of Streptomyces sp.

Authors:  D Roy; A Guha; M K Roy; A C Ghosh
Journal:  Folia Microbiol (Praha)       Date:  1998       Impact factor: 2.099

Review 2.  Directed evolution and rational approaches to improving Streptomyces clavuligerus deacetoxycephalosporin C synthase for cephalosporin production.

Authors:  Kian-Sim Goo; Chun-Song Chua; Tiow-Suan Sim
Journal:  J Ind Microbiol Biotechnol       Date:  2009-03-07       Impact factor: 3.346
  2 in total

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