Literature DB >> 9520448

The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells.

R Wang1, A Nelson, K Kimachi, H M Grey, A G Farr.   

Abstract

A thymic epithelial cell line transfected with I-Ek was used in reaggregate cultures to study the role of peptides in positive selection of T cell receptor transgenic thymocytes. In this system, positive selection of CD4 SP cells occurred only after the addition of exogenous peptide. Analysis of antigen analogs indicated an inverse relationship between the antigenicity for peripheral T cells and the concentration of peptide required for positive selection. These data are most consistent with an avidity (rather than an affinity) model of positive selection, in which ligand density and the affinity of T cell receptor act in concert to determine the fate of developing thymocytes.

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Year:  1998        PMID： 9520448      PMCID： PMC19918          DOI： 10.1073/pnas.95.7.3804

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  22 in total

1.  Differential T cell signaling induced by antagonist peptide-MHC complexes and the associated phenotypic responses.

Authors:  D M La Face; C Couture; K Anderson; G Shih; J Alexander; A Sette; T Mustelin; A Altman; H M Grey
Journal:  J Immunol       Date:  1997-03-01       Impact factor: 5.422

2.  T cells can be activated by peptides that are unrelated in sequence to their selecting peptide.

Authors:  L Ignatowicz; W Rees; R Pacholczyk; H Ignatowicz; E Kushnir; J Kappler; P Marrack
Journal:  Immunity       Date:  1997-08       Impact factor: 31.745

3.  Selection of a broad repertoire of CD4+ T cells in H-2Ma0/0 mice.

Authors:  S Tourne; T Miyazaki; A Oxenius; L Klein; T Fehr; B Kyewski; C Benoist; D Mathis
Journal:  Immunity       Date:  1997-08       Impact factor: 31.745

4.  Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells.

Authors:  K A Hogquist; S C Jameson; M J Bevan
Journal:  Immunity       Date:  1995-07       Impact factor: 31.745

5.  Characteristics of an in vitro system of thymocyte positive selection.

Authors:  G Anderson; J J Owen; N C Moore; E J Jenkinson
Journal:  J Immunol       Date:  1994-09-01       Impact factor: 5.422

Review 6.  The responses of mature T cells are not necessarily antagonized by their positively selecting peptide.

Authors:  L Ignatowicz; J Kappler; D C Parker; P Marrack
Journal:  J Immunol       Date:  1996-09-01       Impact factor: 5.422

7.  Peptide antagonists that promote positive selection are inefficient at T cell activation and thymocyte deletion.

Authors:  M J Barnden; W R Heath; S Rodda; F R Carbone
Journal:  Eur J Immunol       Date:  1994-10       Impact factor: 5.532

8.  The influence of invariant chain on the positive selection of single T cell receptor specificities.

Authors:  S Tourne; N Nakano; S Viville; C Benoist; D Mathis
Journal:  Eur J Immunol       Date:  1995-07       Impact factor: 5.532

9.  Mature T cell reactivity altered by peptide agonist that induces positive selection.

Authors:  E Sebzda; T M Kündig; C T Thomson; K Aoki; S Y Mak; J P Mayer; T Zamborelli; S G Nathenson; P S Ohashi
Journal:  J Exp Med       Date:  1996-03-01       Impact factor: 14.307

10.  Thymic selection and cell division.

Authors:  B Ernst; C D Surh; J Sprent
Journal:  J Exp Med       Date:  1995-10-01       Impact factor: 14.307
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  6 in total

1.  Interactions between double positive thymocytes and high affinity ligands presented by cortical epithelial cells generate double negative thymocytes with T cell regulatory activity.

Authors:  Rongfang Wang; Yiran Wang-Zhu; Howard Grey
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-12       Impact factor: 11.205

Review 2.  Immunological self/nonself discrimination: integration of self vs nonself during cognate T cell interactions with antigen-presenting cells.

Authors:  M D Mannie
Journal:  Immunol Res       Date:  1999       Impact factor: 2.829

3.  Positive selection of CD4(+) T cells is induced in vivo by agonist and inhibited by antagonist peptides.

Authors:  P Kraj; R Pacholczyk; H Ignatowicz; P Kisielow; P Jensen; L Ignatowicz
Journal:  J Exp Med       Date:  2001-08-20       Impact factor: 14.307

4.  Functional reprogramming of the primary immune response by T cell receptor antagonism.

Authors:  Dipica Haribhai; Brandon Edwards; Mary L Williams; Calvin B Williams
Journal:  J Exp Med       Date:  2004-11-22       Impact factor: 14.307

5.  An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells.

Authors:  Wan-Lin Lo; Nathan J Felix; James J Walters; Henry Rohrs; Michael L Gross; Paul M Allen
Journal:  Nat Immunol       Date:  2009-10-04       Impact factor: 25.606

6.  Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression.

Authors:  Phillip M Garfin; Dullei Min; Jerrod L Bryson; Thomas Serwold; Badreddin Edris; Clare C Blackburn; Ellen R Richie; Kenneth I Weinberg; Nancy R Manley; Julien Sage; Patrick Viatour
Journal:  J Exp Med       Date:  2013-05-13       Impact factor: 14.307
  6 in total

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