Literature DB >> 7914216

Characteristics of an in vitro system of thymocyte positive selection.

G Anderson1, J J Owen, N C Moore, E J Jenkinson.   

Abstract

We investigated the phenotypic changes accompanying maturation of CD4+CD8+ thymocytes in the presence of thymic stomal cells in vitro. Many of the features that are characteristic of positive selection in vivo, such as an ordered down-regulation of CD4 or CD8 together with up-regulation of the TCR-alpha beta complex, also occurred in vitro. Transient expression of CD69 was also observed, together with activation of IL-2 and IL-4 cytokine genes, providing further evidence that positive selection in vitro involves a pattern of gene regulation comparable to that seen in vivo.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7914216

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  11 in total

Review 1.  Review article: thymus organ cultures and T-cell receptor repertoire development.

Authors:  G Anderson; E J Jenkinson
Journal:  Immunology       Date:  2000-08       Impact factor: 7.397

2.  The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells.

Authors:  R Wang; A Nelson; K Kimachi; H M Grey; A G Farr
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-31       Impact factor: 11.205

3.  Expression patterns of Ikaros family members during positive selection and lineage commitment of human thymocytes.

Authors:  Julie L Mitchell; Amara Seng; Thomas M Yankee
Journal:  Immunology       Date:  2016-09-20       Impact factor: 7.397

4.  Impaired expression of MHC class II molecules in response to interferon-gamma (IFN-gamma) on human thymoma neoplastic epithelial cells.

Authors:  M Inoue; M Okumura; S Miyoshi; H Shiono; K Fukuhara; Y Kadota; R Shirakura; H Matsuda
Journal:  Clin Exp Immunol       Date:  1999-07       Impact factor: 4.330

5.  Asynchronous coreceptor downregulation after positive thymic selection: prolonged maintenance of the double positive state in CD8 lineage differentiation due to sustained biosynthesis of the CD4 coreceptor.

Authors:  T Barthlott; H Kohler; K Eichmann
Journal:  J Exp Med       Date:  1997-01-20       Impact factor: 14.307

6.  Neoplastic thymic epithelial cells of human thymoma support T cell development from CD4-CD8- cells to CD4+CD8+ cells in vitro.

Authors:  M Inoue; Y Fujii; M Okumura; Y Takeuchi; H Shiono; S Miyoshi; H Matsuda; R Shirakura
Journal:  Clin Exp Immunol       Date:  1998-06       Impact factor: 4.330

7.  Increased thymocyte CD4+CD8+ cells and T-cell receptor beta gene rearrangements in thymoma.

Authors:  Motoki Sakuraba; Toshiko Motoji; Sumio Nitta; Hideaki Mizoguchi; Takamasa Ohnuki
Journal:  Jpn J Thorac Cardiovasc Surg       Date:  2003-10

8.  How many thymocytes audition for selection?

Authors:  M Merkenschlager; D Graf; M Lovatt; U Bommhardt; R Zamoyska; A G Fisher
Journal:  J Exp Med       Date:  1997-10-06       Impact factor: 14.307

9.  Requirement of CD3 complex-associated signaling functions for expression of rearranged T cell receptor beta VDJ genes in early thymic development.

Authors:  A Würch; J Biro; A J Potocnik; I Falk; H Mossmann; K Eichmann
Journal:  J Exp Med       Date:  1998-11-02       Impact factor: 14.307

10.  Recombinant IL-7/HGFβ hybrid cytokine enhances T cell recovery in mice following allogeneic bone marrow transplantation.

Authors:  Laijun Lai; Mingfeng Zhang; Yinhong Song; Debra Rood
Journal:  PLoS One       Date:  2013-12-12       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.