OBJECTIVE: To study the antiviral effect and predictors of response to two- and three-drug regimens amongst antiretroviral-naive individuals using an intent-to-treat analysis. MAIN OUTCOME MEASURE: Suppression of plasma viral load to < 500 copies/ml. PATIENTS: A total of 420 (264 double drug, 156 triple drug) individuals in a province-wide treatment programme were studied. RESULTS: A decrease in plasma viral load to < 500 copies/ml was documented in 197 (47%) subjects. This was independently associated with a lower baseline plasma viral load (odds ratio, 3.67; 95% confidence interval, 2.13-6.30) and initiation onto a three-drug regimen (odds ratio, 3.86; 95% confidence interval, 2.24-6.66). Median plasma viral load failed to reach < 500 copies/ml and in fact rebounded in the two-drug group. In contrast, 91 (58%) subjects receiving three drugs reached < 500 copies/ml during the study period. CONCLUSION: These results support the use of powerful triple drug regimens as initial therapy in HIV-infected individuals.
OBJECTIVE: To study the antiviral effect and predictors of response to two- and three-drug regimens amongst antiretroviral-naive individuals using an intent-to-treat analysis. MAIN OUTCOME MEASURE: Suppression of plasma viral load to < 500 copies/ml. PATIENTS: A total of 420 (264 double drug, 156 triple drug) individuals in a province-wide treatment programme were studied. RESULTS: A decrease in plasma viral load to < 500 copies/ml was documented in 197 (47%) subjects. This was independently associated with a lower baseline plasma viral load (odds ratio, 3.67; 95% confidence interval, 2.13-6.30) and initiation onto a three-drug regimen (odds ratio, 3.86; 95% confidence interval, 2.24-6.66). Median plasma viral load failed to reach < 500 copies/ml and in fact rebounded in the two-drug group. In contrast, 91 (58%) subjects receiving three drugs reached < 500 copies/ml during the study period. CONCLUSION: These results support the use of powerful triple drug regimens as initial therapy in HIV-infected individuals.
Authors: J M Raboud; E Seminari; S L Rae; P R Harrigan; R S Hogg; B Conway; C Sherlock; M T Schechter; M V O'Shaughnessy; J S Montaner Journal: J Clin Microbiol Date: 1998-11 Impact factor: 5.948
Authors: Sophie Patterson; Angela Cescon; Hasina Samji; Zishan Cui; Benita Yip; Katherine J Lepik; David Moore; Viviane D Lima; Bohdan Nosyk; P Richard Harrigan; Julio S G Montaner; Kate Shannon; Evan Wood; Robert S Hogg Journal: Int J Epidemiol Date: 2014-03-17 Impact factor: 7.196
Authors: N A Mohd Salleh; N Fairbairn; S Nolan; R Barrios; J Shoveller; L Richardson; M-J Milloy Journal: HIV Med Date: 2019-07-29 Impact factor: 3.180
Authors: A H Anis; D Guh; R S Hogg; X H Wang; B Yip; K J Craib; M V O'Shaughnessy; M T Schechter; J S Montaner Journal: Pharmacoeconomics Date: 2000-10 Impact factor: 4.981