Literature DB >> 9515715

Detection of chromosomal gains and losses in comparative genomic hybridization analysis based on standard reference intervals.

M Kirchhoff1, T Gerdes, H Rose, J Maahr, A M Ottesen, C Lundsteen.   

Abstract

Criteria for detection of chromosome aberrations by Comparative Genomic Hybridization (CGH) are not standardized and improvement of this part of the analysis is of paramount importance to the applicability of the technique. The aim of this work was to suggest CGH detection criteria that increase the specificity and sensitivity and at the same time include chromosome regions previously excluded from CGH analysis. We analyzed 33 hybridizations with normal DNA and modified our CGH software in order to use a selection of these normal analyses as a model for interpretation of analyses of unknown samples. This approach was successfully tested on 14 samples with known aberrations.

Mesh：

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Year:  1998        PMID： 9515715

Source DB:  PubMed          Journal:  Cytometry        ISSN： 0196-4763


  22 in total

Review 1.  Comparative genomic hybridisation.

Authors:  M M Weiss; M A Hermsen; G A Meijer; N C van Grieken; J P Baak; E J Kuipers; P J van Diest
Journal:  Mol Pathol       Date:  1999-10

2.  High resolution comparative genomic hybridisation in clinical cytogenetics.

Authors:  M Kirchhoff; H Rose; C Lundsteen
Journal:  J Med Genet       Date:  2001-11       Impact factor: 6.318

3.  Genetic imbalances with impact on survival in head and neck cancer patients.

Authors:  U Bockmühl; K Schlüns; I Küchler; S Petersen; I Petersen
Journal:  Am J Pathol       Date:  2000-08       Impact factor: 4.307

4.  TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions.

Authors:  Nuno Cerveira; Franclim R Ribeiro; Ana Peixoto; Vera Costa; Rui Henrique; Carmen Jerónimo; Manuel R Teixeira
Journal:  Neoplasia       Date:  2006-10       Impact factor: 5.715

5.  Chromosome copy number changes carry prognostic information independent of KIT/PDGFRA point mutations in gastrointestinal stromal tumors.

Authors:  Mara Silva; Isabel Veiga; Franclim R Ribeiro; Joana Vieira; Carla Pinto; Manuela Pinheiro; Bárbara Mesquita; Catarina Santos; Marta Soares; José Dinis; Lúcio Santos; Paula Lopes; Mariana Afonso; Carlos Lopes; Manuel R Teixeira
Journal:  BMC Med       Date:  2010-05-14       Impact factor: 8.775

Review 6.  Recent Trends in System-Scale Integrative Approaches for Discovering Protective Antigens Against Mycobacterial Pathogens.

Authors:  Aarti Rana; Shweta Thakur; Girish Kumar; Yusuf Akhter
Journal:  Front Genet       Date:  2018-11-27       Impact factor: 4.599

7.  Molecular cytogenetic analysis of prostatic adenocarcinomas from screening studies : early cancers may contain aggressive genetic features.

Authors:  J C Alers; P J Krijtenburg; A N Vis; R F Hoedemaeker; M F Wildhagen; W C Hop; T T van Der Kwast; F H Schröder; H J Tanke; H van Dekken
Journal:  Am J Pathol       Date:  2001-02       Impact factor: 4.307

8.  Genomic instability in pituitary adenomas.

Authors:  Janusz Szymas; Karsten Schluens; Wlodzimierz Liebert; Iver Petersen
Journal:  Pituitary       Date:  2002       Impact factor: 4.107

9.  Mapping genomic deletions down to the base: a quantitative copy number scanning approach used to characterise and clone the breakpoints of a recurrent 7p14.2p15.3 deletion.

Authors:  Morten Dunø; Hanne Hove; Maria Kirchhoff; Koenraad Devriendt; Marianne Schwartz
Journal:  Hum Genet       Date:  2004-09-18       Impact factor: 4.132

10.  Tumor spreading to the contralateral ovary in bilateral ovarian carcinoma is a late event in clonal evolution.

Authors:  Francesca Micci; Lisbeth Haugom; Terje Ahlquist; Vera M Abeler; Claes G Trope; Ragnhild A Lothe; Sverre Heim
Journal:  J Oncol       Date:  2009-09-15       Impact factor: 4.375
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