| Literature DB >> 9512347 |
Y Tanaka1, M Mizokami, E Orito, K Ohba, T Kato, Y Kondo, I Mboudjeka, L Zekeng, L Kaptue, B Bikandou, P M'Pele, J Takehisa, M Hayami, Y Suzuki, T Gojobori.
Abstract
Ninety-four GB virus C/hepatitis G virus (GBV-C/ HGV) RNA-positive serum samples were obtained from all over the world. We found that all 15 GBV-C/HGV isolates from the Pygmies and the Bantu in the Central African region had a 12-amino acid indel (i.e. insertion or deletion) in the non-structural protein (NS) 5A region. Phylogenetic analyses of the NS5A region, using GBV-A as an outgroup, showed that these 15 isolates had diverged from the common ancestor much earlier than the remaining isolates, indicating an African origin of GBV-C/HGV.Entities:
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Year: 1998 PMID： 9512347 DOI： 10.1016/s0014-5793(98)00083-0
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124