Literature DB >> 9508541

Delayed gastric emptying by Helicobacter pylori lipopolysaccharide in conscious rats.

T Okumura1, E Shoji, N Takahashi, H Wakebe, K Imagawa, M Kikuchi, Y Kohgo.   

Abstract

The present study was carried out to investigate the possibility that lipopolysaccharide deprived from Helicobacter pylori may alter gastric motility. To address the question, we examined the effect of H. pylori lipopolysaccharide on gastric emptying in conscious rats. Gastric emptying was evaluated by the phenol red method. Time-course and dose-related effects of intraperitoneal administration of H. pylori lipopolysaccharide were investigated. Intraperitoneal injection of H. pylori lipopolysaccharide significantly suppressed gastric emptying of a liquid meal in a dose-dependent manner. The inhibitory action of H. pylori lipopolysaccharide was observed 2, 4, 8, or 12 hr after the injection. These results suggest for the first time that H. pylori lipopolysaccharide may suppress gastric emptying in a long-lasting fashion. It is also suggested that H. pylori may influence gastric function through its cell wall structure named lipopolysaccharide.

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Year:  1998        PMID： 9508541     DOI： 10.1023/a:1018828105226

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  39 in total

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Journal:  Biochem Biophys Res Commun       Date:  1992-05-15       Impact factor: 3.575

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4.  Basic fibroblast growth factor (bFGF) acts centrally in the brain to inhibit gastric emptying in rats.

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Journal:  Neurosci Lett       Date:  1992-03-16       Impact factor: 3.046

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Journal:  Gastroenterology       Date:  1995-01       Impact factor: 22.682

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Journal:  Rev Infect Dis       Date:  1984 Jan-Feb

Review 8.  Hypotheses on the pathogenesis and natural history of Helicobacter pylori-induced inflammation.

Authors:  M J Blaser
Journal:  Gastroenterology       Date:  1992-02       Impact factor: 22.682

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Authors:  T Okumura; T N Pappas; I L Taylor
Journal:  Neurosci Lett       Date:  1994-08-29       Impact factor: 3.046

10.  Interleukin-1 is cytoprotective, antisecretory, stimulates PGE2 synthesis by the stomach, and retards gastric emptying.

Authors:  A Robert; A S Olafsson; C Lancaster; W R Zhang
Journal:  Life Sci       Date:  1991       Impact factor: 5.037
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  6 in total

1.  Electrogastrographic characteristics in patients of stomach cancer.

Authors:  F Y Chang; C L Lu; C Y Chen; S D Lee; C W Wu; S T Young; H C Wu; T S Kuo
Journal:  Dig Dis Sci       Date:  2001-07       Impact factor: 3.199

2.  Identification of a D-glycero-D-manno-heptosyltransferase gene from Helicobacter pylori.

Authors:  Koji Hiratsuka; Susan M Logan; J Wayne Conlan; Vandana Chandan; Annie Aubry; Natalia Smirnova; Heather Ulrichsen; Kenneth H N Chan; Douglas W Griffith; Blair A Harrison; Jianjun Li; Eleonora Altman
Journal:  J Bacteriol       Date:  2005-08       Impact factor: 3.490

3.  Gastric emptying is altered with the presence of gastritis.

Authors:  Erin L Symonds; Cuong D Tran; Ross N Butler; Taher I Omari
Journal:  Dig Dis Sci       Date:  2007-08-31       Impact factor: 3.199

4.  Involvement of serotonin and nitric oxide in endotoxin-induced gastric motility changes in conscious rats.

Authors:  Toshio Watanabe; Takeshi Tomomasa; Hiroaki Kaneko; Atsushi Takahashi; Masahiko Tabata; Sarwar Hussain; Akihiro Morikawa
Journal:  Dig Dis Sci       Date:  2002-06       Impact factor: 3.199

5.  IL-1 receptor antagonist blocks the lipopolysaccharide-induced inhibition of gastric motility in freely moving conscious rats.

Authors:  Yoshihiro Tsuchiya; Tsukasa Nozu; Shima Kumei; Masumi Ohhira; Toshikatsu Okumura
Journal:  Dig Dis Sci       Date:  2012-05-19       Impact factor: 3.199

6.  Lipopolysaccharide reduces food passage rate from the crop by a prostaglandin-independent mechanism in chickens.

Authors:  T Tachibana; M Ogino; R Makino; M S I Khan; M A Cline
Journal:  Br Poult Sci       Date:  2016-12-02       Impact factor: 2.095
  6 in total

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