| Literature DB >> 950645 |
Abstract
The synthesis of a series of halogenated 1-benzylindazole-3-carboxylic acids and related derivatives is described. These compounds were studied for their effect on testicular weight and on the inhibition of spermatogenesis. Many of the derivatives, but in particular 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid (11), 1-(2,4-dibromobenzyl)-1H-indazole-3-carboxylic acid (13), 1-(4-chloro-2-methylbenzyl)-1H-indazole-3-carboxylic acid (27), and their glycerol esters, showed potent antispermatogenic activity.Entities:
Keywords: Animals, Laboratory; Biology; Clinical Research; Contraception; Contraceptive Agents; Contraceptive Agents, Male; Examinations And Diagnoses; Family Planning; Genitalia; Genitalia, Male; Laboratory Examinations And Diagnoses; Laboratory Procedures; Physiology; Research Methodology; Spermatogenesis Blocking Agents; Testis; Urogenital System
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Year: 1976 PMID： 950645 DOI： 10.1021/jm00228a008
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446