Literature DB >> 9503277

Catechol-O-methyltransferase genotype and susceptibility to Parkinson's disease in Japan. Short communication.

A Yoritaka1, N Hattori, H Yoshino, Y Mizuno.   

Abstract

We report -108Met/Val polymorphism of the COMT gene in Japanese patients with Parkinson's disease (PD). The allele frequency for -108Val was higher in PD patients compared with controls, although the differences did not reach the statistical significance. However, the frequency of -108Val homozygotes was significantly higher in PD patients (56.8%) than in control subjects (44.2%), and heterozygotes of -108Met/Val were less in PD. COMT gene polymorphism may constitute a genetic risk factor for PD among Japanese.

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Year:  1997        PMID: 9503277     DOI: 10.1007/BF01294732

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN: 0300-9564            Impact factor:   3.575


  13 in total

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