Literature DB >> 1542252

Electrophoretic analysis of low and high activity forms of catechol-O-methyltransferase in human erythrocytes.

M H Grossman1, C Szumlanski, J B Littrell, R Weinstein, R M Weinshilboum.   

Abstract

Analysis of the catechol-O-methyltransferase (COMT) enzyme in human RBC lysates from 15 samples exhibiting inherited variations in level of activity and thermal stability was performed. Electrophoretic blotting and immune fixation was carried out following sodium dodecyl sulfate polyacrylamide gel electrophoresis or isoelectric focusing of lysate protein. These techniques did not reveal a major structural alteration of the protein that could account for the observed variation in enzyme activity or thermal stability. Future studies utilizing molecular genetic techniques should make it possible to determine the basis for inherited variations in human RBC COMT activity and thermal stability.

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Year:  1992        PMID： 1542252     DOI： 10.1016/0024-3205(92)90386-4

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  7 in total

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  7 in total

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