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Literature DB >> 9502109

Azole derivatives of 1,4-benzothiazine as antifungal agents.

R Fringuelli¹, F Schiaffella, F Bistoni, L Pitzurra, A Vecchiarelli.

Abstract

A series of azole derivatives of 1,4-benzothiazine 7-14 was synthesized and evaluated for the in vitro and in vivo activity against Candida albicans. Secondary alcohol 10 and its ether derivative 13 showed very good efficacy against systemic candidiasis in a murine experimental model.

Entities: Chemical Disease Species

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Year: 1998 PMID： 9502109 DOI： 10.1016/s0968-0896(97)10016-5

Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641

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Cited

6 in total

1. A new azole derivative of 1,4-benzothiazine increases the antifungal mechanisms of natural effector cells.

Authors: L Pitzurra; R Fringuelli; S Perito; F Schiaffella; R Barluzzi; F Bistoni; A Vecchiarelli
Journal: Antimicrob Agents Chemother Date: 1999-09 Impact factor: 5.191

2. Crystal structure of (E)-2-benzyl-idene-4-[(3-phenyl-4,5-di-hydro-isoxazol-5-yl)meth-yl]-2H-benzo[b][1,4]thia-zin-3(4H)-one.

Authors: Nada Kheira Sebbar; Mohamed Ellouz; El Mokhtar Essassi; Mohamed Saadi; Lahcen El Ammari
Journal: Acta Crystallogr E Crystallogr Commun Date: 2015-05-23

6. Chemoenzymatic synthesis and biological evaluation of enantiomerically enriched 1-(β-hydroxypropyl)imidazolium- and triazolium-based ionic liquids.

Authors: Paweł Borowiecki; Małgorzata Milner-Krawczyk; Jan Plenkiewicz
Journal: Beilstein J Org Chem Date: 2013-03-12 Impact factor: 2.883

6 in total

Azole derivatives of 1,4-benzothiazine as antifungal agents.

1. A new azole derivative of 1,4-benzothiazine increases the antifungal mechanisms of natural effector cells.

2. Crystal structure of (E)-2-benzyl-idene-4-[(3-phenyl-4,5-di-hydro-isoxazol-5-yl)meth-yl]-2H-benzo[b][1,4]thia-zin-3(4H)-one.

3. Ethyl 2-{5-[(3-oxo-3,4-di-hydro-2H-1,4-benzo-thia-zin-4-yl)meth-yl]-1H-1,2,3-triazol-1-yl}acetate.

4. (2Z)-2-Benzyl-idene-4-(prop-2-yn-1-yl)-2H-1,4-benzo-thia-zin-3(4H)-one.

5. Synthesis and antibacterial activity of new 1,2,3-triazolylmethyl-2H-1,4-benzothiazin-3(4H)-one derivatives.

6. Chemoenzymatic synthesis and biological evaluation of enantiomerically enriched 1-(β-hydroxypropyl)imidazolium- and triazolium-based ionic liquids.