Literature DB >> 9501976

Antigen processing: HLA-DO--a hitchhiking inhibitor of HLA-DM.

P E Jensen1.   

Abstract

Recent studies have revealed that the conserved major histocompatibility complex class II molecule, HLA-DO, inhibits the class II antigen-processing pathway. HLA-DO, expressed in only a subset of antigen-presenting cells, binds HLA-DM and blocks HLA-DM-catalyzed peptide loading of class II molecules.

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Year:  1998        PMID： 9501976     DOI： 10.1016/s0960-9822(98)70988-1

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  11 in total

1.  Dissociation of peripheral T cell responses from thymocyte negative selection by weak agonists supports a spare receptor model of T cell activation.

Authors:  Lisa K McNeil; Brian D Evavold
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-19       Impact factor: 11.205

2.  Carrying yourself: self antigen composition of the lymphatic fluid.

Authors:  Laura Santambrogio; Lawrence J Stern
Journal:  Lymphat Res Biol       Date:  2013-09-11       Impact factor: 2.589

3.  The lymph as a pool of self-antigens.

Authors:  Cristina C Clement; Olaf Rotzschke; Laura Santambrogio
Journal:  Trends Immunol       Date:  2010-12-01       Impact factor: 16.687

4.  Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence.

Authors:  Woelsung Yi; Nilufer P Seth; Tom Martillotti; Kai W Wucherpfennig; Derek B Sant'Angelo; Lisa K Denzin
Journal:  J Clin Invest       Date:  2010-04       Impact factor: 14.808

Review 5.  Conformational variation in structures of classical and non-classical MHCII proteins and functional implications.

Authors:  Corrie A Painter; Lawrence J Stern
Journal:  Immunol Rev       Date:  2012-11       Impact factor: 12.988

6.  Evidence for a human leucocyte antigen-DM-induced structural change in human leucocyte antigen-DObeta.

Authors:  Francis Deshaies; Djibril A Diallo; Jean-Simon Fortin; Helen M O'Rourke; Abdul Mohammad Pezeshki; Angélique Bellemare-Pelletier; Nicola Raby; Nathalie Bédard; Alexandre Brunet; Lisa K Denzin; Jacques Thibodeau
Journal:  Immunology       Date:  2008-11-14       Impact factor: 7.397

7.  HLA-DO as the optimizer of epitope selection for MHC class II antigen presentation.

Authors:  Yuri O Poluektov; Aeryon Kim; Isamu Z Hartman; Scheherazade Sadegh-Nasseri
Journal:  PLoS One       Date:  2013-08-08       Impact factor: 3.240

8.  HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.

Authors:  Abigail I Guce; Sarah E Mortimer; Taejin Yoon; Corrie A Painter; Wei Jiang; Elizabeth D Mellins; Lawrence J Stern
Journal:  Nat Struct Mol Biol       Date:  2012-12-09       Impact factor: 15.369

9.  Regulated expression of human histocompatibility leukocyte antigen (HLA)-DO during antigen-dependent and antigen-independent phases of B cell development.

Authors:  Xinjian Chen; Oskar Laur; Taku Kambayashi; Shiyong Li; Robert A Bray; Dominique A Weber; Lars Karlsson; Peter E Jensen
Journal:  J Exp Med       Date:  2002-04-15       Impact factor: 14.307

Review 10.  The lymph self-antigen repertoire.

Authors:  Cristina C Clement; Laura Santambrogio
Journal:  Front Immunol       Date:  2013-12-16       Impact factor: 7.561
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