Literature DB >> 9499110

Application of a Fas ligand encoding a recombinant adenovirus vector for prolongation of transgene expression.

H G Zhang1, G Bilbao, T Zhou, J L Contreras, J Gómez-Navarro, M Feng, I Saito, J D Mountz, D T Curiel.   

Abstract

An adenovirus vector encoding murine Fas ligand (mFasL) under an inducible control was derived. In vivo ectopic expression of mFasL in murine livers induced an inflammatory cellular infiltration. Furthermore, ectopic expression of mFasL by myocytes did not allow prolonged vector-mediated transgene expression. Thus, ectopic expression of functional mFasL in vector-transduced cells does not appear to confer, by itself, an immunoprivileged site sufficient to mitigate adenovirus vector immunogenicity.

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Year:  1998        PMID： 9499110      PMCID： PMC109549          DOI： 10.1128/JVI.72.3.2483-2490.1998

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  65 in total

1.  Prevention of islet allograft rejection with engineered myoblasts expressing FasL in mice.

Authors:  H T Lau; M Yu; A Fontana; C J Stoeckert
Journal:  Science       Date:  1996-07-05       Impact factor: 47.728

Review 2.  Second-generation adenovirus vectors.

Authors:  Q Wang; M H Finer
Journal:  Nat Med       Date:  1996-06       Impact factor: 53.440

Review 3.  Fas-ligand: privilege and peril.

Authors:  D R Green; C F Ware
Journal:  Proc Natl Acad Sci U S A       Date:  1997-06-10       Impact factor: 11.205

4.  Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts.

Authors:  J Allison; H M Georgiou; A Strasser; D L Vaux
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-15       Impact factor: 11.205

5.  [Immunostaining of anti-Fas IgG1 antibody in diseased human muscle].

Authors:  K Sahashi; T Ibi; J Ling
Journal:  Rinsho Shinkeigaku       Date:  1995-07

Review 6.  Adenoviruses as gene-delivery vehicles.

Authors:  J M Wilson
Journal:  N Engl J Med       Date:  1996-05-02       Impact factor: 91.245

7.  Use of transient CD4 lymphocyte depletion to prolong transgene expression of E1-deleted adenoviral vectors.

Authors:  J K Kolls; D Lei; G Odom; S Nelson; W R Summer; M A Gerber; J E Shellito
Journal:  Hum Gene Ther       Date:  1996-03-01       Impact factor: 5.695

8.  Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors.

Authors:  S K Tripathy; H B Black; E Goldwasser; J M Leiden
Journal:  Nat Med       Date:  1996-05       Impact factor: 53.440

9.  Fas (CD95)/Fas ligand interactions regulate antigen-specific, major histocompatibility complex-restricted T/B cell proliferative responses.

Authors:  M Ozdemirli; M El-Khatib; L C Foote; J K Wang; A Marshak-Rothstein; T L Rothstein; S T Ju
Journal:  Eur J Immunol       Date:  1996-02       Impact factor: 5.532

10.  Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells.

Authors:  T Zhou; J Cheng; P Yang; Z Wang; C Liu; X Su; H Bluethmann; J D Mountz
Journal:  J Exp Med       Date:  1996-04-01       Impact factor: 14.307
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  7 in total

1.  Efficient gene activation in cultured mammalian cells mediated by FLP recombinase-expressing recombinant adenovirus.

Authors:  M Nakano; K Odaka; M Ishimura; S Kondo; N Tachikawa; J Chiba; Y Kanegae; I Saito
Journal:  Nucleic Acids Res       Date:  2001-04-01       Impact factor: 16.971

Review 2.  Specific deletion of autoreactive T cells by adenovirus-transfected, Fas ligand-producing antigen-presenting cells.

Authors:  Huang-Ge Zhan; John D Mountz; Martin Fleck; Tong Zhou; Hui-Chen Hsu
Journal:  Immunol Res       Date:  2002       Impact factor: 2.829

3.  Hepatic DR5 induces apoptosis and limits adenovirus gene therapy product expression in the liver.

Authors:  Huang-Ge Zhang; Jinfu Xie; Liang Xu; Pingar Yang; Xin Xu; Sheher Sun; Yongming Wang; David T Curiel; Hui-Chen Hsu; John D Mountz
Journal:  J Virol       Date:  2002-06       Impact factor: 5.103

4.  Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic bcl-2 gene.

Authors:  G Bilbao; J L Contreras; H G Zhang; M J Pike; K Overturf; G Mikheeva; V Krasnykh; D T Curiel
Journal:  J Virol       Date:  1999-08       Impact factor: 5.103

5.  Antigen presenting cells expressing Fas ligand down-modulate chronic inflammatory disease in Fas ligand-deficient mice.

Authors:  H G Zhang; M Fleck; E R Kern; D Liu; Y Wang; H C Hsu; P Yang; Z Wang; D T Curiel; T Zhou; J D Mountz
Journal:  J Clin Invest       Date:  2000-03       Impact factor: 14.808

6.  Inflammation, apoptosis, and necrosis induced by neoadjuvant fas ligand gene therapy improves survival of dogs with spontaneous bone cancer.

Authors:  Jaime F Modiano; Donald Bellgrau; Gary R Cutter; Susan E Lana; Nicole P Ehrhart; Ej Ehrhart; Vicki L Wilke; J Brad Charles; Sibyl Munson; Milcah C Scott; John Pozniak; Cathy S Carlson; Jerome Schaack; Richard C Duke
Journal:  Mol Ther       Date:  2012-07-31       Impact factor: 11.454

Review 7.  Conditional gene expression systems to study herpesvirus biology in vivo.

Authors:  Torsten Sacher; Stefan Jordan; Christian A Mohr; Aurore Vidy; Annelies M G Weyn; Zsolt Ruszics; Ulrich H Koszinowski
Journal:  Med Microbiol Immunol       Date:  2008-03-07       Impact factor: 3.402
  7 in total

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