Literature DB >> 10400798

Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic bcl-2 gene.

G Bilbao1, J L Contreras, H G Zhang, M J Pike, K Overturf, G Mikheeva, V Krasnykh, D T Curiel.   

Abstract

An adenovirus vector encoding the human Bcl-2 gene (hBcl-2) was derived. In vivo expression of hBcl-2 in murine livers enhanced and prolonged adenovirus-mediated gene expression. Furthermore, in the hBcl-2-treated group a significant reduction in the apoptosis induced by the adenovirus vector was observed. Thus, the cytoprotection of the vector-infected cells with antiapoptotic genes appears promising for successful in vivo gene therapy.

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Year:  1999        PMID： 10400798      PMCID： PMC112785     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  80 in total

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Authors:  D A Muruve; M J Barnes; I E Stillman; T A Libermann
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Authors:  R S Hotchkiss; P E Swanson; C M Knudson; K C Chang; J P Cobb; D F Osborne; K M Zollner; T G Buchman; S J Korsmeyer; I E Karl
Journal:  J Immunol       Date:  1999-04-01       Impact factor: 5.422

4.  Interleukin-2-activated natural killer cells can induce both apoptosis and necrosis in rat hepatocytes.

Authors:  W M Blom; H J De Bont; I Meijerman; P J Kuppen; G J Mulder; J F Nagelkerke
Journal:  Hepatology       Date:  1999-03       Impact factor: 17.425

5.  Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death.

Authors:  D Hockenbery; G Nuñez; C Milliman; R D Schreiber; S J Korsmeyer
Journal:  Nature       Date:  1990-11-22       Impact factor: 49.962

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7.  Inhibition of NF-kappaB activation in combination with bcl-2 expression allows for persistence of first-generation adenovirus vectors in the mouse liver.

Authors:  A Lieber; C Y He; L Meuse; C Himeda; C Wilson; M A Kay
Journal:  J Virol       Date:  1998-11       Impact factor: 5.103

8.  cyt gene of adenoviruses 2 and 5 is an oncogene for transforming function in early region E1B and encodes the E1B 19,000-molecular-weight polypeptide.

Authors:  N Takemori; C Cladaras; B Bhat; A J Conley; W S Wold
Journal:  J Virol       Date:  1984-12       Impact factor: 5.103

9.  Mutations in the gene encoding the adenovirus early region 1B 19,000-molecular-weight tumor antigen cause the degradation of chromosomal DNA.

Authors:  E White; T Grodzicker; B W Stillman
Journal:  J Virol       Date:  1984-11       Impact factor: 5.103

10.  Deletion of the gene encoding the adenovirus 5 early region 1b 21,000-molecular-weight polypeptide leads to degradation of viral and host cell DNA.

Authors:  S Pilder; J Logan; T Shenk
Journal:  J Virol       Date:  1984-11       Impact factor: 5.103
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