PURPOSE: To evaluate a new single-electron contrast agent for Overhauser-enhanced MR imaging. The contrast agents that are currently available give enhancement factors that are too low to make the technique a valid option for routine clinical use. MATERIAL AND METHODS: MR images were generated directly following the injection of the substance into rats. The MR scanner was operated at a main magnetic field of 0.01 T and equipped with a separate rf-transmitter tuned to the electron paramagnetic resonance frequency of the contrast agent. RESULTS: As expected, the images generated show a high level of enhancement in areas where the contrast agent was present, and a maximum enhancement of 60 times the normal proton signal was obtained in the vascular area. The signal-to-noise ratios in the images were superior to those previously attained. CONCLUSION: The new contrast agent makes it possible to generate MR images with both morphological and functional information at 0.01 T. The signal-to-noise ratios found in the generated images were of the same order as, or better than, those obtained with the standard clinical routine.
PURPOSE: To evaluate a new single-electron contrast agent for Overhauser-enhanced MR imaging. The contrast agents that are currently available give enhancement factors that are too low to make the technique a valid option for routine clinical use. MATERIAL AND METHODS: MR images were generated directly following the injection of the substance into rats. The MR scanner was operated at a main magnetic field of 0.01 T and equipped with a separate rf-transmitter tuned to the electron paramagnetic resonance frequency of the contrast agent. RESULTS: As expected, the images generated show a high level of enhancement in areas where the contrast agent was present, and a maximum enhancement of 60 times the normal proton signal was obtained in the vascular area. The signal-to-noise ratios in the images were superior to those previously attained. CONCLUSION: The new contrast agent makes it possible to generate MR images with both morphological and functional information at 0.01 T. The signal-to-noise ratios found in the generated images were of the same order as, or better than, those obtained with the standard clinical routine.
Authors: Andrey A Bobko; Timothy D Eubank; Jeffrey L Voorhees; Olga V Efimova; Igor A Kirilyuk; Sergey Petryakov; Dmitrii G Trofimiov; Clay B Marsh; Jay L Zweier; Igor A Grigor'ev; Alexandre Samouilov; Valery V Khramtsov Journal: Magn Reson Med Date: 2011-11-23 Impact factor: 4.668
Authors: Murali C Krishna; Sean English; Kenichi Yamada; John Yoo; Ramachandran Murugesan; Nallathamby Devasahayam; John A Cook; Klaes Golman; Jan Henrik Ardenkjaer-Larsen; Sankaran Subramanian; James B Mitchell Journal: Proc Natl Acad Sci U S A Date: 2002-02-19 Impact factor: 11.205
Authors: Olga V Efimova; Ziqi Sun; Sergey Petryakov; Eric Kesselring; George L Caia; David Johnson; Jay L Zweier; Valery V Khramtsov; Alexandre Samouilov Journal: J Magn Reson Date: 2011-01-15 Impact factor: 2.229
Authors: Valery V Khramtsov; George L Caia; Keerthi Shet; Eric Kesselring; Sergey Petryakov; Jay L Zweier; Alexandre Samouilov Journal: J Magn Reson Date: 2009-11-26 Impact factor: 2.229
Authors: Klaes Golman; Jan H Ardenkjaer-Larsen; J Stefan Petersson; Sven Mansson; Ib Leunbach Journal: Proc Natl Acad Sci U S A Date: 2003-08-20 Impact factor: 11.205
Authors: Victor Ruiz-Rodado; Jeffery R Brender; Murali K Cherukuri; Mark R Gilbert; Mioara Larion Journal: Prog Nucl Magn Reson Spectrosc Date: 2020-12-02 Impact factor: 9.795