Literature DB >> 949503

The metabolism of l-[3-3h]lactate by isolated hamster liver cells.

R Rognstad, P Wals.   

Abstract

The rate of tritium removal from L-[3-3H]lactate by hamster liver cells is faster than the analytical rate of lactate utilization, or the rate of 14C disappearance from 6-[U-14C, 3-3H]Llactate decrease. However, addition of low concentrations (0.1 to 1.0 mM) of L-cycloserine, a glutamate pyruvate transaminase inhibitor, nearly equalizes the rates of isotope utilization from L-[3-3H]lactate and L-[U-14C]lactate. The results suggest a very limited rate of recycling of phosphoenolpyruvate back to pyruvate during gluconeogenesis from lactate in fasted hamster liver cells.

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Year:  1976        PMID： 949503     DOI： 10.1016/0304-4165(76)90343-3

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  8 in total

1.  Studies of pyruvate-water isotope exchange catalysed by erythrocytes and proteins.

Authors:  R J Simpson; K M Brindle; F F Brown; I D Campbell; D L Foxall
Journal:  Biochem J       Date:  1981-02-01       Impact factor: 3.857

2.  Lactate metabolism in the perfused rat hindlimb.

Authors:  M Shiota; S Golden; J Katz
Journal:  Biochem J       Date:  1984-09-01       Impact factor: 3.857

3.  Acute effects of ethanol on the perfused rat liver. Studies on lipid and carbohydrate metabolism, substrate cycling and perfusate amino acids.

Authors:  D L Topping; D G Clark; G B Storer; R P Trimble; R J Illman
Journal:  Biochem J       Date:  1979-10-15       Impact factor: 3.857

4.  Effects of fructose concentration on carbohydrate metabolism, heat production and substrate cycling in isolated rat hepatocytes.

Authors:  D G Clark; O H Filsell; D L Topping
Journal:  Biochem J       Date:  1979-12-15       Impact factor: 3.857

5.  Mild type II diabetes markedly increases glucose cycling in the postabsorptive state and during glucose infusion irrespective of obesity.

Authors:  S Efendic; S Karlander; M Vranic
Journal:  J Clin Invest       Date:  1988-06       Impact factor: 14.808

6.  Use of 2H2O for estimating rates of gluconeogenesis. Application to the fasted state.

Authors:  B R Landau; J Wahren; V Chandramouli; W C Schumann; K Ekberg; S C Kalhan
Journal:  J Clin Invest       Date:  1995-01       Impact factor: 14.808

7.  The determination of lactate turnover in vivo with 3H- and 14C-labelled lactate. The significance of sites of tracer administration and sampling.

Authors:  J Katz; F Okajima; M Chenoweth; A Dunn
Journal:  Biochem J       Date:  1981-02-15       Impact factor: 3.857

8.  Metabolism of 3H- and 14C-labelled lactate in starved rats.

Authors:  F Okajima; M Chenoweth; R Rognstad; A Dunn; J Katz
Journal:  Biochem J       Date:  1981-02-15       Impact factor: 3.857
  8 in total

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