| Literature DB >> 9493590 |
F Burzotta1, A Di Castelnuovo, C Amore, A D'Orazio, R Di Bitondo, M B Donati, L Iacoviello.
Abstract
The PAI-1 gene promoter 4G/5G polymorphism was found to be associated with plasma PAI-1 activity in Northern and Central Europe populations, but no data are available on the association between this polymorphism and PAI-1 levels in Southern Europe countries (such as Italy) where the incidence of ischemic disorders is lower. This study shows that among populations with different incidence of atherothrombotic disorders the 4G/5G PAI-1 gene promoter polymorphism has the same importance in the regulation of plasma PAI-1 activity. Moreover, we have analysed some gene-environmental interactions: the correlation between PAI-1 and cholesterol in non dyslipidemic subjects and the correlation between PAI-1 activity and tryglicerides in dyslipidemic subjects differed according to the 4G/5G genotype class. Thus, our findings suggest that, among subjects with or without metabolic disorders such as dyslipidemia, completely different gene-environment interactions may occur.Entities:
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Year: 1998 PMID： 9493590
Source DB: PubMed Journal: Thromb Haemost ISSN： 0340-6245 Impact factor: 5.249