Literature DB >> 9487733

Expression genetics: a different approach to cancer diagnosis and prognosis.

M Zhang1, K J Martin, S Sheng, R Sager.   

Abstract

Expression genetics is a new approach to the identification of cancer-related genes. Instead of studying gene mutations at the genome level, it focuses on the investigation of heredity at the RNA level. By isolating genes whose expression is up or down regulated in cancers, expression geneticists study their function in the context of gene regulation. A major goal of expression genetics in cancer is to correct gene expression in tumors by the application of potential therapeutic agents.

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Year:  1998        PMID: 9487733     DOI: 10.1016/s0167-7799(97)01157-8

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN: 0167-7799            Impact factor:   19.536


  6 in total

Review 1.  Technology that will initiate future revolutionary changes in healthcare and the clinical laboratory.

Authors:  R M Nakamura
Journal:  J Clin Lab Anal       Date:  1999       Impact factor: 2.352

2.  AZU-1: a candidate breast tumor suppressor and biomarker for tumor progression.

Authors:  H M Chen; K L Schmeichel; I S Mian; S Lelièvre; O W Petersen; M J Bissell
Journal:  Mol Biol Cell       Date:  2000-04       Impact factor: 4.138

3.  Re-expression of SPR1 in breast cancer cells by phorbol 12-myristate 13-acetate (PMA) or UV irradiation is mediated by the AP-1 binding site in the SPR1 promoter.

Authors:  A Anisowicz; G Sotiropoulou; R Sager
Journal:  Mol Med       Date:  1999-08       Impact factor: 6.354

4.  Epigenetic Silencing of ALDH1L1, a Metabolic Regulator of Cellular Proliferation, in Cancers.

Authors:  Natalia V Oleinik; Natalia I Krupenko; Sergey A Krupenko
Journal:  Genes Cancer       Date:  2011-02

5.  Identification of tumor markers using two-dimensional electrophoresis in gastric carcinoma.

Authors:  Kai-Juan Wang; Run-Tian Wang; Jian-Zhong Zhang
Journal:  World J Gastroenterol       Date:  2004-08-01       Impact factor: 5.742

6.  Gelsolin suppresses tumorigenicity through inhibiting PKC activation in a human lung cancer cell line, PC10.

Authors:  N Sagawa; H Fujita; Y Banno; Y Nozawa; H Katoh; N Kuzumaki
Journal:  Br J Cancer       Date:  2003-02-24       Impact factor: 7.640

  6 in total

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