Literature DB >> 10102131

Technology that will initiate future revolutionary changes in healthcare and the clinical laboratory.

R M Nakamura1.   

Abstract

Future trends in healthcare delivery will focus on preventive medicine that will require integration of molecular medicine with advanced information and computer technology. Molecular medicine will shift from costly intervention and treatment of established diseases to proactive prediction and prevention of disease risks. This approach will require new informatic systems that will link large scale databanks and special programs for data mining and retrieval in bioinformatics, cheminformatics, and population genetics. The clinical laboratory will soon be able to provide powerful new molecular diagnostic tools along with multianalytic assays for expression of genes and proteins in different patterns of diseases, disease progression, and predisposition to diseases.

Mesh:

Year:  1999        PMID: 10102131      PMCID: PMC6807936     

Source DB:  PubMed          Journal:  J Clin Lab Anal        ISSN: 0887-8013            Impact factor:   2.352


  15 in total

Review 1.  Microarrays: biotechnology's discovery platform for functional genomics.

Authors:  M Schena; R A Heller; T P Theriault; K Konrad; E Lachenmeier; R W Davis
Journal:  Trends Biotechnol       Date:  1998-07       Impact factor: 19.536

Review 2.  Do we know what inappropriate laboratory utilization is? A systematic review of laboratory clinical audits.

Authors:  C van Walraven; C D Naylor
Journal:  JAMA       Date:  1998-08-12       Impact factor: 56.272

3.  Evolving catalytic antibodies in a phage-displayed combinatorial library.

Authors:  I Fujii; S Fukuyama; Y Iwabuchi; R Tanimura
Journal:  Nat Biotechnol       Date:  1998-05       Impact factor: 54.908

4.  Molecular medicine and information-based targeted healthcare.

Authors:  G Poste
Journal:  Nat Biotechnol       Date:  1998-05       Impact factor: 54.908

5.  Biotechnology's metamorphosis into a drug discovery industry.

Authors:  J Drews
Journal:  Nat Biotechnol       Date:  1998-05       Impact factor: 54.908

Review 6.  Predictive medicine in autoimmune diseases: from the identification of genetic predisposition and environmental influence to precocious immunotherapy.

Authors:  J F Bach
Journal:  Clin Immunol Immunopathol       Date:  1994-08

Review 7.  Factors influencing changes in the clinical immunology laboratory.

Authors:  R M Nakamura; D J Bylund
Journal:  Clin Chem       Date:  1994-11       Impact factor: 8.327

Review 8.  Human antibodies by design.

Authors:  T J Vaughan; J K Osbourn; P R Tempest
Journal:  Nat Biotechnol       Date:  1998-06       Impact factor: 54.908

Review 9.  A framework for clinical evaluation of diagnostic technologies.

Authors:  G H Guyatt; P X Tugwell; D H Feeny; R B Haynes; M Drummond
Journal:  CMAJ       Date:  1986-03-15       Impact factor: 8.262

10.  Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library.

Authors:  T J Vaughan; A J Williams; K Pritchard; J K Osbourn; A R Pope; J C Earnshaw; J McCafferty; R A Hodits; J Wilton; K S Johnson
Journal:  Nat Biotechnol       Date:  1996-03       Impact factor: 54.908

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  2 in total

Review 1.  Perspective on the clinical laboratory: new uses for informatics.

Authors:  R A McPherson
Journal:  J Clin Lab Anal       Date:  1999       Impact factor: 2.352

2.  Linking biomedical language information and knowledge resources: GO and UMLS.

Authors:  I N Sarkar; M N Cantor; R Gelman; F Hartel; Y A Lussier
Journal:  Pac Symp Biocomput       Date:  2003
  2 in total

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