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Literature DB >> 948757

Modulation of C3b hemolytic activity by a plasma protein distinct from C3b inactivator.

Abstract

A human plasma protein binds to cell-bound C3b, the major cleavage product of the third component of complement. Consequent upon this binding, C3b no longer functions in either the classical or alternative pathways. This C3b inhibitory activity is a property of a protein previously designated beta 1H on the basis of its electrophoretic mobility.

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Year: 1976 PMID： 948757 DOI： 10.1126/science.948757

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

48 in total

1. Factor H-IgG Chimeric Proteins as a Therapeutic Approach against the Gram-Positive Bacterial Pathogen Streptococcus pyogenes.

Authors: Anna M Blom; Michal Magda; Lisa Kohl; Jutamas Shaughnessy; John D Lambris; Sanjay Ram; David Ermert
Journal: J Immunol Date: 2017-10-30 Impact factor: 5.422

2. The C-terminus of factor H: monoclonal antibodies inhibit heparin binding and identify epitopes common to factor H and factor H-related proteins.

Authors: W M Prodinger; J Hellwage; M Spruth; M P Dierich; P F Zipfel
Journal: Biochem J Date: 1998-04-01 Impact factor: 3.857

3. Initiation of the alternative pathway of complement: recognition of activators by bound C3b and assembly of the entire pathway from six isolated proteins.

Authors: R D Schreiber; M K Pangburn; P H Lesavre; H J Müller-Eberhard
Journal: Proc Natl Acad Sci U S A Date: 1978-08 Impact factor: 11.205

Modulation of C3b hemolytic activity by a plasma protein distinct from C3b inactivator.

1. Factor H-IgG Chimeric Proteins as a Therapeutic Approach against the Gram-Positive Bacterial Pathogen Streptococcus pyogenes.

2. The C-terminus of factor H: monoclonal antibodies inhibit heparin binding and identify epitopes common to factor H and factor H-related proteins.

3. Initiation of the alternative pathway of complement: recognition of activators by bound C3b and assembly of the entire pathway from six isolated proteins.

4. Complement factor H-binding protein of Raji cells and tonsil B lymphocytes.

5. Modulation of the classical pathway C3 convertase by plasma proteins C4 binding protein and C3b inactivator.

6. Regulation of complement membrane attack complex formation in myocardial infarction.

Review 7. Genetics and complement in atypical HUS.

8. Isolation of two molecular populations of human complement factor H by hydrophobic affinity chromatography.

9. Complement activation in chronic liver disease.

10. A general method for affinity purification of complement component C3b using factor H-sepharose.