Literature DB >> 9484604

Microtubules and actin filaments: dynamic targets for cancer chemotherapy.

M A Jordan1, L Wilson.   

Abstract

Microtubules and actin filaments play important roles in mitosis, cell signaling, and motility. Thus these cytoskeletal filaments are the targets of a growing number of anti-cancer drugs. In this review we summarize the current understanding of the mechanisms of these drugs in relation to microtubule and actin filament polymerization and dynamics. In addition, we outline how, by targeting microtubules, drugs inhibit cell proliferation by blocking mitosis at the mitotic checkpoint and inducing apoptosis. The beta-tubulin isotype specificities of new anticancer drugs and the antitumor potential of agents that act on the actin cytoskeleton are also discussed.

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Year:  1998        PMID： 9484604     DOI： 10.1016/s0955-0674(98)80095-1

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  140 in total

1.  Active erk regulates microtubule stability in H-ras-transformed cells.

Authors:  R E Harrison; E A Turley
Journal:  Neoplasia       Date:  2001 Sep-Oct       Impact factor: 5.715

2.  Novel suicide ligands of tubulin arrest cancer cells in S-phase.

Authors:  A Davis; J D Jiang; K M Middleton; Y Wang; I Weisz; Y H Ling; J G Bekesi
Journal:  Neoplasia       Date:  1999-12       Impact factor: 5.715

Review 3.  Mechanisms of Taxol resistance related to microtubules.

Authors:  George A Orr; Pascal Verdier-Pinard; Hayley McDaid; Susan Band Horwitz
Journal:  Oncogene       Date:  2003-10-20       Impact factor: 9.867

4.  G(1) and G(2) cell-cycle arrest following microtubule depolymerization in human breast cancer cells.

Authors:  April L Blajeski; Vy A Phan; Timothy J Kottke; Scott H Kaufmann
Journal:  J Clin Invest       Date:  2002-07       Impact factor: 14.808

5.  RNAi in cultured Drosophila cells.

Authors:  Ling-Rong Kao; Timothy L Megraw
Journal:  Methods Mol Biol       Date:  2004

Review 6.  Antimicrotubular drugs binding to vinca domain of tubulin.

Authors:  Suvroma Gupta; Bhabatarak Bhattacharyya
Journal:  Mol Cell Biochem       Date:  2003-11       Impact factor: 3.396

7.  Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition.

Authors:  Mathias V Schmidt; Jan-Philip Schülke; Claudia Liebl; Michael Stiess; Charilaos Avrabos; Jörg Bock; Gabriela M Wochnik; Heather A Davies; Nicole Zimmermann; Sebastian H Scharf; Dietrich Trümbach; Wolfgang Wurst; Walter Zieglgänsberger; Christoph Turck; Florian Holsboer; Michael G Stewart; Frank Bradke; Matthias Eder; Marianne B Müller; Theo Rein
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-03       Impact factor: 11.205

8.  Characterization of the colchicine binding site on avian tubulin isotype betaVI.

Authors:  Shubhada Sharma; Barbara Poliks; Colby Chiauzzi; Rudravajhala Ravindra; Adam R Blanden; Susan Bane
Journal:  Biochemistry       Date:  2010-04-06       Impact factor: 3.162

9.  A Click Chemistry Approach to Identify Protein Targets of Cancer Chemopreventive Phenethyl Isothiocyanate.

Authors:  Ying Fu; Lixin Mi; Miloslav Sanda; Shana Silverstein; Monika Aggarwal; Deyun Wang; Pankaj Gupta; Radoslav Goldman; Daniel H Appella; Fung-Lung Chung
Journal:  RSC Adv       Date:  2014       Impact factor: 3.361

10.  The methyl ester of okadaic acid is more potent than okadaic acid in disrupting the actin cytoskeleton and metabolism of primary cultured hepatocytes.

Authors:  Begoña Espiña; M Carmen Louzao; Eva Cagide; Amparo Alfonso; Mercedes R Vieytes; Takeshi Yasumoto; Luis M Botana
Journal:  Br J Pharmacol       Date:  2009-12-15       Impact factor: 8.739
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