Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A Click Chemistry Approach to Identify Protein Targets of Cancer Chemopreventive Phenethyl Isothiocyanate.

Literature DB >> 28725420

A Click Chemistry Approach to Identify Protein Targets of Cancer Chemopreventive Phenethyl Isothiocyanate.

Ying Fu¹, Lixin Mi¹, Miloslav Sanda¹, Shana Silverstein¹, Monika Aggarwal¹, Deyun Wang², Pankaj Gupta², Radoslav Goldman¹, Daniel H Appella², Fung-Lung Chung¹.

Abstract

Here we report the identification of protein targets of chemopreventive phenethyl isothiocyanate (PEITC) via "click" chemistry in the A549 human lung cancer cell line, using a novel alkyne-tagged PEITC which was also found to show potent in vitro anticancer activity.

Entities: CellLine Chemical Disease Gene Species

Year: 2014 PMID： 28725420 PMCID： PMC5512166 DOI： 10.1039/C3RA46849F

Source DB: PubMed Journal: RSC Adv ISSN： 2046-2069 Impact factor: 3.361

24 in total

1. Identification of potential protein targets of isothiocyanates by proteomics.

Authors: Lixin Mi; Brian L Hood; Nicolas A Stewart; Zhen Xiao; Sudha Govind; Xiantao Wang; Thomas P Conrads; Timothy D Veenstra; Fung-Lung Chung
Journal: Chem Res Toxicol Date: 2011-08-26 Impact factor: 3.739

Review 2. Cu-catalyzed azide-alkyne cycloaddition.

Authors: Morten Meldal; Christian Wenzel Tornøe
Journal: Chem Rev Date: 2008-08 Impact factor: 60.622

Review 3. Microtubules and actin filaments: dynamic targets for cancer chemotherapy.

Authors: M A Jordan; L Wilson
Journal: Curr Opin Cell Biol Date: 1998-02 Impact factor: 8.382

4. Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate, and 6-phenylhexyl isothiocyanate: apoptotic index as a biomarker in colon cancer chemoprevention and promotion.

Authors: H S Samaha; G J Kelloff; V Steele; C V Rao; B S Reddy
Journal: Cancer Res Date: 1997-04-01 Impact factor: 12.701

Review 5. Proteins as binding targets of isothiocyanates in cancer prevention.

Authors: Lixin Mi; Anthony J Di Pasqua; Fung-Lung Chung
Journal: Carcinogenesis Date: 2011-06-10 Impact factor: 4.944

6. Analysis of glucosinolates, isothiocyanates, and amine degradation products in vegetable extracts and blood plasma by LC-MS/MS.

Authors: Lijiang Song; John J Morrison; Nigel P Botting; Paul J Thornalley
Journal: Anal Biochem Date: 2005-10-21 Impact factor: 3.365

7. Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer.

Authors: Anna A Powolny; Ajay Bommareddy; Eun-Ryeong Hahm; Daniel P Normolle; Jan H Beumer; Joel B Nelson; Shivendra V Singh
Journal: J Natl Cancer Inst Date: 2011-02-17 Impact factor: 13.506

8. Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives.

Authors: Andrew Vila; Keri A Tallman; Aaron T Jacobs; Daniel C Liebler; Ned A Porter; Lawrence J Marnett
Journal: Chem Res Toxicol Date: 2008-01-31 Impact factor: 3.739

A Click Chemistry Approach to Identify Protein Targets of Cancer Chemopreventive Phenethyl Isothiocyanate.

1. Identification of potential protein targets of isothiocyanates by proteomics.

Review 2. Cu-catalyzed azide-alkyne cycloaddition.

Review 3. Microtubules and actin filaments: dynamic targets for cancer chemotherapy.

4. Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate, and 6-phenylhexyl isothiocyanate: apoptotic index as a biomarker in colon cancer chemoprevention and promotion.

Review 5. Proteins as binding targets of isothiocyanates in cancer prevention.

6. Analysis of glucosinolates, isothiocyanates, and amine degradation products in vegetable extracts and blood plasma by LC-MS/MS.

7. Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer.

8. Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives.

9. Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic Phase 2 enzymes.

10. Bioconjugation by copper(I)-catalyzed azide-alkyne [3 + 2] cycloaddition.

Review 1. Sulforaphane and Its Bifunctional Analogs: Synthesis and Biological Activity.

2. Synthesis of Isothiocyanates Using DMT/NMM/TsO^- as a New Desulfurization Reagent.

Review 3. Bifunctional Non-Canonical Amino Acids: Combining Photo-Crosslinking with Click Chemistry.