Literature DB >> 9482899

Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells.

S Zhou1, P Buckhaults, L Zawel, F Bunz, G Riggins, J L Dai, S E Kern, K W Kinzler, B Vogelstein.   

Abstract

Smad4 (DPC4) is a candidate tumor suppressor gene that has been hypothesized to be critical for transmitting signals from transforming growth factor (TGF) beta and related ligands. To directly test this hypothesis, the Smad4 gene was deleted through homologous recombination in human colorectal cancer cells. This deletion abrogated signaling from TGF-beta, as well as from the TGF-beta family member activin. These results provide unequivocal evidence that mutational inactivation of Smad4 causes TGF-beta unresponsiveness and provide a basis for understanding the physiologic role of this gene in tumorigenesis.

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Year:  1998        PMID： 9482899      PMCID： PMC19358          DOI： 10.1073/pnas.95.5.2412

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  56 in total

1.  Responsiveness of three newly established human colorectal cancer cell lines to transforming growth factors beta 1 and beta 2.

Authors:  L Suardet; A C Gaide; J M Calmès; B Sordat; J C Givel; J F Eliason; N Odartchenko
Journal:  Cancer Res       Date:  1992-07-01       Impact factor: 12.701

2.  MADR1, a MAD-related protein that functions in BMP2 signaling pathways.

Authors:  P A Hoodless; T Haerry; S Abdollah; M Stapleton; M B O'Connor; L Attisano; J L Wrana
Journal:  Cell       Date:  1996-05-17       Impact factor: 41.582

3.  Mad-related genes in the human.

Authors:  G J Riggins; S Thiagalingam; E Rozenblum; C L Weinstein; S E Kern; S R Hamilton; J K Willson; S D Markowitz; K W Kinzler; B Vogelstein
Journal:  Nat Genet       Date:  1996-07       Impact factor: 38.330

4.  Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers.

Authors:  S Thiagalingam; C Lengauer; F S Leach; M Schutte; S A Hahn; J Overhauser; J K Willson; S Markowitz; S R Hamilton; S E Kern; K W Kinzler; B Vogelstein
Journal:  Nat Genet       Date:  1996-07       Impact factor: 38.330

5.  Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1.

Authors:  R J Lechleider; M P de Caestecker; A Dehejia; M H Polymeropoulos; A B Roberts
Journal:  J Biol Chem       Date:  1996-07-26       Impact factor: 5.157

6.  Isolation of a cDNA encoding a murine UDPgalactose:beta-D-galactosyl- 1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase: expression cloning by gene transfer.

Authors:  R D Larsen; V P Rajan; M M Ruff; J Kukowska-Latallo; R D Cummings; J B Lowe
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

7.  Transforming growth factor beta 1 acts as an autocrine-negative growth regulator in colon enterocytic differentiation but not in goblet cell maturation.

Authors:  M M Hafez; D Infante; S Winawer; E Friedman
Journal:  Cell Growth Differ       Date:  1990-12

8.  A human Mad protein acting as a BMP-regulated transcriptional activator.

Authors:  F Liu; A Hata; J C Baker; J Doody; J Cárcamo; R M Harland; J Massagué
Journal:  Nature       Date:  1996-06-13       Impact factor: 49.962

9.  Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta.

Authors:  M R Keeton; S A Curriden; A J van Zonneveld; D J Loskutoff
Journal:  J Biol Chem       Date:  1991-12-05       Impact factor: 5.157

10.  Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor.

Authors:  G H Thomsen
Journal:  Development       Date:  1996-08       Impact factor: 6.868
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  46 in total

1.  Overexpression of Evi-1 oncoprotein represses TGF-β signaling in colorectal cancer.

Authors:  Xiyun Deng; Yanna Cao; Yan Liu; Fazhi Li; Kamalanathan Sambandam; Srinivasan Rajaraman; Archibald S Perkins; Alan P Fields; Mark R Hellmich; Courtney M Townsend; E Aubrey Thompson; Tien C Ko
Journal:  Mol Carcinog       Date:  2011-12-07       Impact factor: 4.784

2.  TGF-beta signaling in colon cancer cells.

Authors:  Fazhi Li; Yanna Cao; Courtney M Townsend; Tien C Ko
Journal:  World J Surg       Date:  2005-03       Impact factor: 3.352

3.  Nuclear localization of Dpc4 (Madh4, Smad4) in colorectal carcinomas and relation to mismatch repair/transforming growth factor-beta receptor defects.

Authors:  E Montgomery; M Goggins; S Zhou; P Argani; R Wilentz; M Kaushal; S Booker; K Romans; P Bhargava; R Hruban; S Kern
Journal:  Am J Pathol       Date:  2001-02       Impact factor: 4.307

4.  Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas : a new marker of DPC4 inactivation.

Authors:  R E Wilentz; G H Su; J L Dai; A B Sparks; P Argani; T A Sohn; C J Yeo; S E Kern; R H Hruban
Journal:  Am J Pathol       Date:  2000-01       Impact factor: 4.307

5.  DEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities.

Authors:  Leigh Zawel; Jian Yu; Christopher J Torrance; Sanford Markowitz; Kenneth W Kinzler; Bert Vogelstein; Shibin Zhou
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-05       Impact factor: 11.205

6.  G1 cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: phenotypes reversed by a tumorigenic mutation.

Authors:  J L Dai; R K Bansal; S E Kern
Journal:  Proc Natl Acad Sci U S A       Date:  1999-02-16       Impact factor: 11.205

7.  Smad signaling is required to maintain epigenetic silencing during breast cancer progression.

Authors:  Panagiotis Papageorgis; Arthur W Lambert; Sait Ozturk; Fangming Gao; Hongjie Pan; Upender Manne; Yuriy O Alekseyev; Arunthathi Thiagalingam; Hamid M Abdolmaleky; Marc Lenburg; Sam Thiagalingam
Journal:  Cancer Res       Date:  2010-01-19       Impact factor: 12.701

8.  Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer.

Authors:  Anja Sterner-Kock; Irmgard S Thorey; Katri Koli; Frank Wempe; Jürgen Otte; Thorsten Bangsow; Katharina Kuhlmeier; Thomas Kirchner; Shenchu Jin; Jorma Keski-Oja; Harald von Melchner
Journal:  Genes Dev       Date:  2002-09-01       Impact factor: 11.361

9.  CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells.

Authors:  J N Topper; M R DiChiara; J D Brown; A J Williams; D Falb; T Collins; M A Gimbrone
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-04       Impact factor: 11.205

10.  The genomics of colorectal cancer: state of the art.

Authors:  Andrew D Beggs; Shirley V Hodgson
Journal:  Curr Genomics       Date:  2008-03       Impact factor: 2.236
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