Literature DB >> 8663601

Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1.

R J Lechleider1, M P de Caestecker, A Dehejia, M H Polymeropoulos, A B Roberts.   

Abstract

The transforming growth factor-beta (TGF-beta) superfamily regulates a multitude of cellular and developmental events. TGF-beta family ligands signal through transmembrane serine/threonine kinase receptors whose downstream effectors are largely unknown. Using genetic data from the fruit fly, we have identified a downstream effector of TGF-beta-induced signaling. TGF-beta signaling protein-1 (BSP-1) is rapidly phosphorylated in response to TGF-beta. Localization of bsp-1 to chromosome 4q28 suggests a role in carcinogenesis. These data suggest that BSP-1 is the prototype of a new class of signaling molecules.

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Year:  1996        PMID： 8663601     DOI： 10.1074/jbc.271.30.17617

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  17 in total

1.  Fibrodysplasia ossificans progressiva, a heritable disorder of severe heterotopic ossification, maps to human chromosome 4q27-31.

Authors:  G Feldman; M Li; S Martin; M Urbanek; J A Urtizberea; M Fardeau; M LeMerrer; J M Connor; J Triffitt; R Smith; M Muenke; F S Kaplan; E M Shore
Journal:  Am J Hum Genet       Date:  2000-01       Impact factor: 11.025

2.  Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases.

Authors:  M P de Caestecker; W T Parks; C J Frank; P Castagnino; D P Bottaro; A B Roberts; R J Lechleider
Journal:  Genes Dev       Date:  1998-06-01       Impact factor: 11.361

3.  Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein.

Authors:  J M Yingling; M B Datto; C Wong; J P Frederick; N T Liberati; X F Wang
Journal:  Mol Cell Biol       Date:  1997-12       Impact factor: 4.272

4.  TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4.

Authors:  A Nakao; T Imamura; S Souchelnytskyi; M Kawabata; A Ishisaki; E Oeda; K Tamaki; J Hanai; C H Heldin; K Miyazono; P ten Dijke
Journal:  EMBO J       Date:  1997-09-01       Impact factor: 11.598

5.  Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells.

Authors:  S Zhou; P Buckhaults; L Zawel; F Bunz; G Riggins; J L Dai; S E Kern; K W Kinzler; B Vogelstein
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-03       Impact factor: 11.205

6.  Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis.

Authors:  James S Hagood; Priya Prabhakaran; Pallavi Kumbla; Lorena Salazar; Mark W MacEwen; Thomas H Barker; Luis A Ortiz; Trenton Schoeb; Gene P Siegal; C Bruce Alexander; Annie Pardo; Moisés Selman
Journal:  Am J Pathol       Date:  2005-08       Impact factor: 4.307

7.  Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin.

Authors:  Roy Baas; Ayestha Sijm; Hetty A A M van Teeffelen; Robert van Es; Harmjan R Vos; H Th Marc Timmers
Journal:  J Biol Chem       Date:  2016-10-04       Impact factor: 5.157

8.  Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction.

Authors:  M B Datto; J P Frederick; L Pan; A J Borton; Y Zhuang; X F Wang
Journal:  Mol Cell Biol       Date:  1999-04       Impact factor: 4.272

9.  SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta.

Authors:  L Vindevoghel; R J Lechleider; A Kon; M P de Caestecker; J Uitto; A B Roberts; A Mauviel
Journal:  Proc Natl Acad Sci U S A       Date:  1998-12-08       Impact factor: 11.205

10.  Distinct endocytic responses of heteromeric and homomeric transforming growth factor beta receptors.

Authors:  R A Anders; S L Arline; J J Doré; E B Leof
Journal:  Mol Biol Cell       Date:  1997-11       Impact factor: 4.138
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