Literature DB >> 9482269

Ischemia induces a reduction in the content of ulinastatin-like substance in the murine hippocampus.

T Shikimi1, T Gonda, M Takahashi, H Kaneto, H Okunishi, S Takaori.   

Abstract

Effects of ischemia on the content of a ulinastatin (UT)-like substance in the murine cerebral cortex and hippocampus were studied. At 24 h post-ischemia, a significant (p < 0.05) decrease in the content of UT-like substance in the hippocampus but not the cerebral cortex and a concurrent increase in the activity of micro-calpain were observed. In in vitro experiments, a decrease was registered in the content of UT-like substance in the hippocampus in the presence of calcium. This decrease was inhibited by both EDTA and calpastatin treatments. These results implicate the destruction of UT-like substance by micro-calpain in the ischemic hippocampus.

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Year:  1998        PMID： 9482269     DOI： 10.1023/a:1022453504527

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  22 in total

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Journal:  Brain Res       Date:  1993-04-23       Impact factor: 3.252
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