Literature DB >> 1479747

Existence of a human urinary trypsin inhibitor (urinastatin)-like substance in the rat brain.

T Shikimi1, K Hattori, S Takaori.   

Abstract

A human urinary trypsin inhibitor, urinastatin (UT)-like immunoreactive substance with trypsin inhibitory activity, was demonstrated in certain brain regions in rats, especially the cerebral cortex, hippocampus and hypothalamus. Although this UT-like substance in the rat brain displayed an N-terminal amino acid sequence similar to that of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), it did not show any GAPDH activity. These results indicate that the UT-like substance in the rat brain is a protein different from GAPDH and indicates a localized distribution within certain brain regions partly related to learning and memory.

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Year:  1992        PMID: 1479747     DOI: 10.1254/jjp.60.97

Source DB:  PubMed          Journal:  Jpn J Pharmacol        ISSN: 0021-5198


  6 in total

1.  Ischemia induces a reduction in the content of ulinastatin-like substance in the murine hippocampus.

Authors:  T Shikimi; T Gonda; M Takahashi; H Kaneto; H Okunishi; S Takaori
Journal:  Neurochem Res       Date:  1998-01       Impact factor: 3.996

2.  Neuroprotection by ulinastatin in experimental autoimmune encephalomyelitis.

Authors:  Yaqing Shu; Yu Yang; Wei Qiu; Zhengqi Lu; Ying Li; Jian Bao; Ming Feng; Xueqiang Hu
Journal:  Neurochem Res       Date:  2011-06-12       Impact factor: 3.996

3.  Salubrious effects of ulinastatin and quercetin alone or in combination in endothelial dysfunction and vascular dementia.

Authors:  Poonam Sharma; Nikita Gaur; Shalini Jayant; B M Sharma; Bhagwat Singh; Harsha Kharkwal; Bhupesh Sharma
Journal:  Pharmacol Rep       Date:  2022-04-09       Impact factor: 3.024

4.  Ontogeny of inter-alpha inhibitor proteins in ovine brain and somatic tissues.

Authors:  Mariya S Spasova; Grazyna B Sadowska; Steven W Threlkeld; Yow-Pin Lim; Barbara S Stonestreet
Journal:  Exp Biol Med (Maywood)       Date:  2014-06

5.  Ulinastatin Exhibits Antinociception in Rat Models of Acute Somatic and Visceral Pain Through Inhibiting the Local and Central Inflammation.

Authors:  Mei-Xiang Zhan; Li Tang; Yun-Fei Lu; Huang-Hui Wu; Yi-Qing Zou; Zhi-Bin Guo; Zhong-Mou Shi; Chen-Long Yang; Fei Yang; Guo-Zhong Chen
Journal:  J Pain Res       Date:  2021-05-04       Impact factor: 3.133

6.  Efficacy of Ulinastatin and Sulforaphane Alone or in Combination in Rat Model of Streptozotocin Diabetes Induced Vascular Dementia.

Authors:  Poonam Sharma; Prachi Kaushik; Swati Jain; Brij Mohan Sharma; Rajendra Awasthi; Giriraj Thirupathirao Kulkarni; Bhupesh Sharma
Journal:  Clin Psychopharmacol Neurosci       Date:  2021-08-31       Impact factor: 2.582

  6 in total

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