OBJECTIVE: To examine the effect of phosphate supplements on calcium homeostasis and bone turnover in young men. DESIGN: Study 1 was a randomised, controlled, cross-over trial of 1000 mg elemental phosphate given for one week, with a standard diet of 800 mg/d each of calcium and phosphorus. Study 2 was an escalating dose study of 0, 1000, 1500 and 2000 mg/d elemental phosphate, each given for one week, with a standard diet of 1000 mg/d each of calcium and phosphate. SETTING: Northern General Hospital, Sheffield. SUBJECTS: Study 1, 10 healthy men ages 19-32 y. Study 2, 12 healthy men ages 19-38 y. INTERVENTIONS:Sodium acid phosphate tablets each containing 500 mg elemental phosphorus (16.1 mmol/d), given with meals. RESULTS: Study 1, administration of 32.2 mmol/d phosphorus resulted in a mean increase of 13.2 mmol/d urinary phosphorus, a mean decrease of 1.1 mmol/d urinary calcium, and a mean increase of 7 ng/mL in serum intact PTH. There were no changes in serum phosphate, osteocalcin or urinary N-telopeptide excretion. Study 2, administration of 64.4 mmol/d phosphorus resulted in a mean increase of 27.2 mmol/d urinary phosphorus, a mean decrease of 2.4 mmol/d urinary calcium, with no change in serum phosphate, PTH or urinary deoxypyridinoline. CONCLUSIONS:Phosphate supplementation of the diet does not affect bone turnover in young men.
RCT Entities:
OBJECTIVE: To examine the effect of phosphate supplements on calcium homeostasis and bone turnover in young men. DESIGN: Study 1 was a randomised, controlled, cross-over trial of 1000 mg elemental phosphate given for one week, with a standard diet of 800 mg/d each of calcium and phosphorus. Study 2 was an escalating dose study of 0, 1000, 1500 and 2000 mg/d elemental phosphate, each given for one week, with a standard diet of 1000 mg/d each of calcium and phosphate. SETTING: Northern General Hospital, Sheffield. SUBJECTS: Study 1, 10 healthy men ages 19-32 y. Study 2, 12 healthy men ages 19-38 y. INTERVENTIONS:Sodium acid phosphate tablets each containing 500 mg elemental phosphorus (16.1 mmol/d), given with meals. RESULTS: Study 1, administration of 32.2 mmol/d phosphorus resulted in a mean increase of 13.2 mmol/d urinary phosphorus, a mean decrease of 1.1 mmol/d urinary calcium, and a mean increase of 7 ng/mL in serum intact PTH. There were no changes in serum phosphate, osteocalcin or urinary N-telopeptide excretion. Study 2, administration of 64.4 mmol/d phosphorus resulted in a mean increase of 27.2 mmol/d urinary phosphorus, a mean decrease of 2.4 mmol/d urinary calcium, with no change in serum phosphate, PTH or urinary deoxypyridinoline. CONCLUSIONS:Phosphate supplementation of the diet does not affect bone turnover in young men.
Authors: Colby J Vorland; Elizabeth R Stremke; Ranjani N Moorthi; Kathleen M Hill Gallant Journal: Curr Osteoporos Rep Date: 2017-10 Impact factor: 5.096
Authors: Danielle de Carvalho Pereira; Raquel Patrícia Ataíde Lima; Roberto Teixeira de Lima; Maria da Conceição Rodrigues Gonçalves; Liana Clébia Soares Lima de Morais; Sylvia do Carmo Castro Franceschini; Rosália Gouveia Filizola; Ronei Marcos de Moraes; Luiza Sonia Rios Asciutti; Maria José de Carvalho Costa Journal: Nutr J Date: 2013-06-27 Impact factor: 3.271