OBJECTIVE: To investigate the effect of chronic captopril and enalapril treatment on zinc metabolism in hypertensive patients by assessing zinc levels in serum, urine and monocytes. METHODS:Patients with newly diagnosed essential hypertension were randomly divided into two treatment groups: those treated with captopril only (n = 16) and those treated with enalapril only (n = 18). Ten healthy subjects served as controls. Prior to the start of treatment and again 6 months later, zinc was assessed in the serum, in urine collected over 24 hours, and in peripheral blood monocytes. RESULTS: Significant enhancement of 24-hour urinary zinc excretion (micrograms/24 hour) after 6 months of treatment was observed only in the captopril-treated group (p < 0.01). However, intramonocytic zinc levels decreased significantly in both of the treated groups over the same period (p < 0.01 and P < 0.04 in the captopril- and enalapril-treated groups, respectively). CONCLUSION: Treatment of hypertensive patients withcaptopril or enalapril may result in zinc deficiency.
RCT Entities:
OBJECTIVE: To investigate the effect of chronic captopril and enalapril treatment on zinc metabolism in hypertensivepatients by assessing zinc levels in serum, urine and monocytes. METHODS:Patients with newly diagnosed essential hypertension were randomly divided into two treatment groups: those treated with captopril only (n = 16) and those treated with enalapril only (n = 18). Ten healthy subjects served as controls. Prior to the start of treatment and again 6 months later, zinc was assessed in the serum, in urine collected over 24 hours, and in peripheral blood monocytes. RESULTS: Significant enhancement of 24-hour urinary zinc excretion (micrograms/24 hour) after 6 months of treatment was observed only in the captopril-treated group (p < 0.01). However, intramonocytic zinc levels decreased significantly in both of the treated groups over the same period (p < 0.01 and P < 0.04 in the captopril- and enalapril-treated groups, respectively). CONCLUSION: Treatment of hypertensivepatients with captopril or enalapril may result in zinc deficiency.
Authors: Malay S Gandhi; German Kamalov; Atta U Shahbaz; Syamal K Bhattacharya; Robert A Ahokas; Yao Sun; Ivan C Gerling; Karl T Weber Journal: Heart Fail Rev Date: 2011-01 Impact factor: 4.214
Authors: Brian J Borkowski; Yaser Cheema; Atta U Shahbaz; Syamal K Bhattacharya; Karl T Weber Journal: Eur Heart J Date: 2011-03-12 Impact factor: 29.983
Authors: Michael R Seawell; Fahed Al Darazi; Victor Farah; Kodangudi B Ramanathan; Kevin P Newman; Syamal K Bhattacharya; Karl T Weber Journal: Curr Heart Fail Rep Date: 2013-03